A Prospective Randomized Trial Comparing Standard Ligament Reconstruction Tendon Interposition (LRTI) VS Ligament Reconstruction Tendon Interposition (LRTI) With an Interference Screw for Thumb Carpometacarpal Arthritis - Pilot Study

NCT ID: NCT02352610

Last Updated: 2018-07-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-03-31

Study Completion Date

2018-04-30

Brief Summary

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A Prospective Randomized Trial Comparing Standard Ligament Reconstruction Tendon Interposition (LRTI) VS Ligament Reconstruction Tendon Interposition (LRTI) with an interference screw for thumb carpometacarpal arthritis

Detailed Description

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This study will be a prospective randomized trial done in a single academic center. The patients who meet the inclusion criteria and agree to participate in the trial will be scheduled for a first CMC joint procedure. The procedure, standard LRTI or LRTI with a biotenodesis screw, will be allocated in a randomized fashion in the operating room using a sealed opaque envelope. After the surgery the patient will be placed in a spica splint for 1-2 weeks. Following suture removal, a thumb spica cast will be applied for immobilization for a total of 6 weeks of post-operative immobilisation.

The potential population for this study will include all patients with first carpometacarpal joint arthritis that have failed a conservative treatment. The primary outcome will be the thumb subsidence measured as the percentage of trapezial height, which correlates with stability. Subsidence will be measured on stress x-ray under a standard pinch load. Secondary outcomes will be function measured in 4 different ways: the range of motion compared to the contralateral side, pinch and grip strength compared to the other side, the Disabilities of the Arm Shoulder and Hand (DASH) score and the pain score on a visual analogue scale.

Conditions

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Osteoarthritis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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LRTI without a Biotenodesis Screw

Ligament Reconstruction Tendon Interposition without a Biotenodesis Screw

Group Type ACTIVE_COMPARATOR

LRTI

Intervention Type PROCEDURE

LRTI with Biotenodesis Screw

Ligament Reconstruction Tendon Interposition with Biotenodesis Screw

Group Type ACTIVE_COMPARATOR

LRTI

Intervention Type PROCEDURE

Biotenodesis Screw

Intervention Type DEVICE

Interventions

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LRTI

Intervention Type PROCEDURE

Biotenodesis Screw

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* First CMC primary osteoarthritis refractory to conservative treatment
* Patient \>age 18
* Able to read and understand English
* Available for 2 year follow up

Exclusion Criteria

* Inflammatory Arthritis
* Active infection in the first CMC joint
* Concomitant neuropathy
* Previous surgical procedure on the thumb
* Active or status post CRPS
* Severe ¨Z ¨deformity that requires palmar plate advancement
* Unwilling to participate in a research project
* Contralateral first CMC joint surgery
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Andrew Trenholm

OTHER

Sponsor Role lead

Responsible Party

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Andrew Trenholm

Orthopaedic Surgeon

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Queen Elizabeth II Health Sciences Centre

Halifax, Nova Scotia, Canada

Site Status

Countries

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Canada

Other Identifiers

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2015-239

Identifier Type: -

Identifier Source: org_study_id

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