Gait, cOgnitiOn & Decline (GOOD)

NCT ID: NCT02350270

Last Updated: 2015-01-29

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 2800 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-01-31
• Study Completion Date: 2015-12-31

Brief Summary

The main objective of the GOOD initiative was to determine which spatio-temporal gait parameters and/or combination(s) of spatio-temporal gait parameters best differentiate between cognitively healthy individuals (CHI), patients with mild cognitive impairment (MCI) and those with mild and moderate dementia.

Detailed Description

Gait disorders are frequent in individuals with cognitive disorders. However, the profile of spatio-temporal gait parameters in the different cognitive status in aging (from normal cognition to dementia) has been poorly studied. Determining this profile associated with the severity of cognitive disorders may be helpful to understand the complex interplay between gait and cognitive disorders and, thus, may have important implication for the diagnosis process of patients with and without dementia. For instance, defining a motor phenotype of the severity of cognitive disorders by using quantitative gait measurements could be used to improve the prediction and the diagnosis of dementia.

The investigators hypothesized that, compared to CHI, people with MCI and mild dementia could be characterized by specific phenotypes of spatio-temporal gait parameters measured with the GAITRite® system, and that these profiles could be explained by declines in domain-specific cognitive performance.

Conditions

Mild Cognitive Impairment; Mild Dementia; Moderate Dementia; Healthy

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

cognitively healthy individuals (CHI)

CHI were participants without objective cognitive impairment

gait and cognitive testing

Intervention Type: OTHER

mild cognitive impairment (MCI)

MCI was diagnosed if participants met the following criteria: presence of spontaneous cognitive complaints and objective cognitive impairment

gait and cognitive testing

Intervention Type: OTHER

mild and moderate dementia

Diagnoses of dementia were assigned according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV TR, 2000; Association, 2000; 22) at consensus diagnostic case conferences

gait and cognitive testing

Intervention Type: OTHER

Interventions

gait and cognitive testing

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Being 60 years old and older
• Ability to answer questions

Exclusion Criteria

• Opposition to the use of information collected for research purposes

• Minimum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Biomathics

UNKNOWN

Sponsor Role: collaborator

University Hospital, Angers

OTHER_GOV

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Olivier Beauchet, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Angers University Hospital

Locations

University Hospital

Angers, , France

Site Status: RECRUITING

Countries

France

Central Contacts

Olivier Beauchet, MD, PhD

Role: CONTACT

olbeauchet@chu-angers.fr

++33 2 41 35 57 38

Facility Contacts

Olivier Beauchet, MD, PhD

Role: primary

olbeauchet@chu-angers.fr

++33 2 41 35 57 38

Other Identifiers

2014-17

Identifier Type: -

Identifier Source: org_study_id