Efficacy of Oral Probiotic Administration in Patients With Chronic Periodontitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-06-30

Study Completion Date

2016-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this randomized placebo- controlled clinical trial is to evaluate the effects of Lactobacillus rhamnosus SP1- containing probiotic tablets as an adjunct to scaling and root planning (SRP).

Material and methods: Thirty six chronic periodontitis patients will be recruited and monitored clinically, immunologically and microbiologically at baseline, 3 and 6 months after therapy. All patients will receive scaling and root planning and randomly will be assigned over an experimental (SRP + probiotic, n=18) or control (SRP + placebo, n=18) group. The tablets will be used once per day during 3 months.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Efficacy of Oral Probiotic and Antibiotic Administration in Patients With Chronic Periodontitis

NCT02839408

Chronic Periodontitis

UNKNOWN PHASE2

Clinical and Microbiological Effects of Lactobacillus Rhamnosus in Treatment of Gingivitis

NCT02809313

Gingivitis

UNKNOWN PHASE2

Clinical Effect of Lactobacillus Reuteri in Treatment of Gingivitis

NCT02801773

Gingivitis

UNKNOWN PHASE2

Clinical and Microbiological Aspects of Probiotics in Non-surgical Periodontal Therapy.

NCT06063226

Periodontitis Probiotics Non Surgical Periodontal Therapy

UNKNOWN NA

Effect of Probiotics as Supplement to Non-surgical Periodontal Treatment

NCT05518747

Periodontitis

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

-Chronic Periodontitis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Periodontal treatment, Probitic

Periodontal treatment (scaling and root planning) and one tablet containing Lactobacillus rhamnosus SP1 per day during 3 months.

Group Type EXPERIMENTAL

Lactobacillus rhamnosus SP1

Intervention Type OTHER

Tablet containing Lactobacillus rhamnosus SP1

Periodontal treatment

Intervention Type PROCEDURE

Scaling and root planning

Periodontal treatment, talc powder tab

Periodontal treatment (scaling and root planning) and one tablet containing talc powder per day during 3 months

Group Type PLACEBO_COMPARATOR

Talc powder

Intervention Type OTHER

Tablet containing talc powder

Periodontal treatment

Intervention Type PROCEDURE

Scaling and root planning

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Lactobacillus rhamnosus SP1

Tablet containing Lactobacillus rhamnosus SP1

Intervention Type OTHER

Talc powder

Tablet containing talc powder

Intervention Type OTHER

Periodontal treatment

Scaling and root planning

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* ≥14 natural teeth, excluding third molars
* ≥10 posterior teeth
* ≥35 years old
* ≥ 5 teeth with periodontal sites with probing depths ≥5mm, clinical attachment loss ≥3mm
* Bleeding on probing ≥20% of sites
* Extensive bone loss determined radiographically

Exclusion Criteria

* Periodontal treatment before the time of examination
* Systemic illness
* Pregnancy
* Anticoagulant, antibiotics and non- steroid anti- inflammatory therapy in the 6-month period before the study

Minimum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No