Endometrial Gene Expression in Different Protocols of Endometrial Preparation for Embryo Transfer'

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

5 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-12-31

Study Completion Date

2015-04-30

Brief Summary

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Do differences in endometrial gene expression exist after different protocols of endometrial preparation for embryo transfer? The recent apparition of endometrial receptive arrays technology let us know if endometrial is receptive or not in patients with some problems of infertility as implantation failure, for that we want to know if this technology would tell us if the different kind of protocols for endometrial preparation origin differences that could explain some of the founded results.

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Detailed Description

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Do differences in endometrial gene expression exist after different protocols of endometrial preparation for embryo transfer? The clinical results in different publications showed different results, some of them described the natural cycle superior as the substituted cycles, and in contrast other large series showed superior results in substituted cycles than natural but with an increased of pregnancies losses. The recent apparition of endometrial receptive arrays technology let us know if endometrial is receptive or not in patients with some problems of infertility as implantation failure, for that we want to know if this technology would tell us if the different kind of protocols for endometrial preparation origin differences that could explain some of the founded results.

Conditions

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Endometrial

Study Design

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Study Time Perspective

PROSPECTIVE

Study Groups

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pilot study

A total of 5 volunteers from our egg donation program were included in the study with 4 endometrial biopsies for each one after 4 diferente protocols

* Endometrial biopsy after Stimulated cycle
* Endometrial biopsy after Natural Cycle
* Endometrial biopsy after Natural modified cycle: the biopsy is taken seven days after the hCG
* Endometrial biopsy after Hormone Replacement Therapy Cycle

Endometrial Biopsy

Intervention Type PROCEDURE

4 endometrial biopsy

Interventions

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Endometrial Biopsy

4 endometrial biopsy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* age between 18 and 35 years
* regular menstrual cycles (between 25 and 35 days)
* normal basal hormones(follicle-stimulating hormone \[FSH\] and LH \<10 IU/ mL and estradiol \<60 pg/mL)
* normal karyotype
* body massindex between 18 and 25 kg/m2
* negative serology
* normal cervical cytology in the past year, and a vaginal ultrasound without evidence of any pathologic conditions