Effect of Endometrial Scratching on Assisted Reproduction Outcomes: a Randomized Controlled Trial
NCT ID: NCT02180256
Last Updated: 2018-05-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
NA
107 participants
INTERVENTIONAL
2014-09-30
2016-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
NONE
Study Groups
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Endoscratching, non-RIF
Endometrial scratching. Women with no more than 1 previous unsuccessful embryo transfer. Pipelle in the first seven days of the menstrual cycle, just before starting controlled ovarian stimulation.
Endometrial Scratching
The intentional damage to the endometrium performed with the objective of improving the reproductive outcomes of women desiring pregnancy.
Control, non-RIF
No intervention. Women with no more than 1 previous unsuccessful embryo transfer.
No interventions assigned to this group
Endoscratching, RIF
Endometrial scratching. Women with 2 or more previous unsuccessful embryo transfers. Pipelle in the first seven days of the menstrual cycle, just before starting controlled ovarian stimulation.
Endometrial Scratching
The intentional damage to the endometrium performed with the objective of improving the reproductive outcomes of women desiring pregnancy.
Control, RIF
No intervention. Women with 2 or more previous unsuccessful embryo transfers.
No interventions assigned to this group
Interventions
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Endometrial Scratching
The intentional damage to the endometrium performed with the objective of improving the reproductive outcomes of women desiring pregnancy.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* First four days of the menstrual cycle, just before starting controlled ovarian stimulation for planned IVF and fresh embryo transfer.
* Not have performed endometrial scratching in the last 90 days.
Exclusion Criteria
18 Years
FEMALE
No
Sponsors
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Conselho Nacional de Desenvolvimento Científico e Tecnológico
OTHER_GOV
University of Sao Paulo
OTHER
Responsible Party
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Wellington P Martins, MD
Researcher
Principal Investigators
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Wellington P Martins, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Sao Paulo
Locations
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Hc-Fmrp-Usp
Ribeirão Preto, São Paulo, Brazil
Countries
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References
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Nastri CO, Teixeira DM, Ferriani RA, Martins WP. The overlooked endometrial injury underlying hysteroscopy procedures. Reprod Biomed Online. 2014 Jul;29(1):140. doi: 10.1016/j.rbmo.2014.03.021. Epub 2014 Apr 28. No abstract available.
Nastri CO, Ferriani RA, Raine-Fenning N, Martins WP. Endometrial scratching performed in the non-transfer cycle and outcome of assisted reproduction: a randomized controlled trial. Ultrasound Obstet Gynecol. 2013 Oct;42(4):375-82. doi: 10.1002/uog.12539. Epub 2013 Sep 2.
Nastri CO, Teixeira DM, Martins WP. Endometrial injury in the menstrual cycle prior to assisted reproduction techniques to improve reproductive outcomes. Gynecol Endocrinol. 2013 May;29(5):401-2. doi: 10.3109/09513590.2012.760193. Epub 2013 Jan 22. No abstract available.
Nastri CO, Gibreel A, Raine-Fenning N, Maheshwari A, Ferriani RA, Bhattacharya S, Martins WP. Endometrial injury in women undergoing assisted reproductive techniques. Cochrane Database Syst Rev. 2012 Jul 11;(7):CD009517. doi: 10.1002/14651858.CD009517.pub2.
Other Identifiers
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CAAE: 30504514.6.0000.5440
Identifier Type: -
Identifier Source: org_study_id
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