Incidence of Non Receptive Endometrium in Obese Women

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

183 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-08-31

Study Completion Date

2017-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study evaluates the incidence of Non Receptive endometrium in obese infertile women compared to infertile normal weight women using Endometrial Receptivity Array (ERA) test, containing 238 genes, identifying the receptivity status of an endometrial sample and diagnosing the patient's Window of Implantation, regardless of the histological appearance of the sample. An endometrial biopsy is collected from the uterine fundus, either in a natural cycle or in a hormonal replacement therapy (HRT) cycle and the test is performed.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Non Invasive Diagnostic of Endometrial Receptivity

NCT01588223

Endometrial Receptivity Failure

COMPLETED NA

Genomic Endometrial Expression in Obesity

NCT00505986

Obesity and Embryo Implantation

COMPLETED NA

Endometrial Gene Expression in Different Protocols of Endometrial Preparation for Embryo Transfer'

NCT02280798

Endometrial

COMPLETED

Effects of Varied Estrogen Doses on Endometrial Receptivity

NCT02458404

Luteal Phase Defect

COMPLETED

Endometrial Biopsy in Infertile Patients

NCT00064935

Infertility

COMPLETED PHASE3

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Infertility

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Group A

Non Obese patients

Group Type ACTIVE_COMPARATOR

Endometrial Receptivity Array analysis of endometrial biopsy

Intervention Type OTHER

A biopsy of endometrium is peformed and Endometrial Receptivity Array analysis is carried out, as well as analysis of fat distribution and risk factors of Metabolic Syndrome.

Group B

Obese patients

Group Type EXPERIMENTAL

Endometrial Receptivity Array analysis of endometrial biopsy

Intervention Type OTHER

A biopsy of endometrium is peformed and Endometrial Receptivity Array analysis is carried out, as well as analysis of fat distribution and risk factors of Metabolic Syndrome.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Endometrial Receptivity Array analysis of endometrial biopsy

A biopsy of endometrium is peformed and Endometrial Receptivity Array analysis is carried out, as well as analysis of fat distribution and risk factors of Metabolic Syndrome.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Infertile women: \> 1 year of regular unprotected intercourse without evidence of pregnancy.
* Normal uterus by 2D/3D ultrasound scan and/or hysteroscopy
* No endometriosis
* Presence of both ovaries
* \< 45 years old (in ovum donation, outcome parameters are not affected until this age in all the current published studies).

Exclusion Criteria

* Hydrosalpinx
* Stage 3-4 endometriosis diagnosed with ultrasound, laparoscopy/ laparotomy.
* Implantation failure (≥ 4 pre-embryos of good quality transferred without pregnancy)
* Recurrent pregnancy loss (≥ 2 pregnancies biochemical / clinical)

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No