Allergic Transfusion Reactions in Plasma Transfusion

NCT ID: NCT02200692

Last Updated: 2021-06-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

38 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-06-30

Study Completion Date

2018-03-31

Brief Summary

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Allergic transfusion reactions are a common complication of transfusion by blood components containing plasma. This study aims to investigate passive transfer of Immunoglobin E antibodies as a risk factor of allergic reactions to plasma transfusion by use of Solvent Detergent plasma.

Detailed Description

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Prospective observation study, aiming to measure transfer of Immunoglobin E antibodies and other factors associated with allergic complications in patients receiving plasma transfusion. Samples from patients and plasma units will be investigated. Samples frozen until investigation. To assess biological relevance of findings, additional analysis of basophil reactivity will be performed and information on clinical allergy collected by use of a questionaire .

In-patients will be recruited if receiving plasma transfusion during surgery or if an allergic transfusion complication occurs.

Conditions

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Allergy Transfusion Reaction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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plasma transfusion

Patients receiving plasma transfusion.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients receiving plasma transfusion

Exclusion Criteria

\- Patients not able to complete sampling procedure
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Haukeland University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Torunn O Apelseth, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Helse Bergen HF, Haukeland University Hospital

Locations

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Haukeland University Hospital

Bergen, , Norway

Site Status

Countries

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Norway

Other Identifiers

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REK 2014/607

Identifier Type: OTHER

Identifier Source: secondary_id

2014/607

Identifier Type: -

Identifier Source: org_study_id

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