Focus On Stiffness Reduction, Endothelial Function and Autonomic Nervous System

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-12-31

Study Completion Date

2015-03-31

Brief Summary

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Myocardial infarction is related with endothelial function, arterial stiffness and autonomic nervous system dysfunction, but also with arterial hypertension. Hypertension by itself is also related with endothelial function, arterial stiffness and autonomic nervous system dysfunction.

Primary aim of study is to investigate how complex cardiac rehabilitation influence endothelial function, arterial stiffness and autonomic nervous system activity according to presence or absence arterial hypertension.

Secondary aim is to obtain correlation between methods for the assessment of particular disorders and intercorrelation between different disorders for example endothelial function and autonomic nervous system activity.

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Detailed Description

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We expect that in study groups PWV will improve better that in control group. 5% of the limit value of p \<0.05.

We expect that in study groups AASI will improve better that in control group. 5% of the limit value of p \<0.05.

We expect that in study groups AI will improve better that in control group. 5% of the limit value of p \<0.05.

We expect that time and frequency parameters of HRV will increase in study group. 5% of the limit value of p \<0.05.

We expect that parameters of HRT will improve in study group. 5% of the limit value of p \<0.05.

We expect improvement in RHI in study group. 5% of the limit value of p \<0.05.

Conditions

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Arterial Stiffness Endothelial Function Autonomic Nervous System Acute Coronary Syndrome Arterial Hypertension

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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CR with AH

Patients after ACS with arterial hypertension treat with comprehensive cardiac rehabilitation

comprehensive cardiac rehabilitation

Intervention Type OTHER

Standard program of comprehensive cardiac rehabilitation CR with physical activity, behavioral intervention, risk factor modification and intervention.

N-CR with AH

Patients after ACS with arterial hypertension don't treat with comprehensive cardiac rehabilitation.

No interventions assigned to this group

CR without AH

Patients after ACS without arterial hypertension treat with comprehensive cardiac rehabilitation

comprehensive cardiac rehabilitation

Intervention Type OTHER

Standard program of comprehensive cardiac rehabilitation CR with physical activity, behavioral intervention, risk factor modification and intervention.

Interventions

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comprehensive cardiac rehabilitation

Standard program of comprehensive cardiac rehabilitation CR with physical activity, behavioral intervention, risk factor modification and intervention.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* after a recent troponin-positive acute coronary syndrome (within 7-30 days) treated by means of primary coronary angioplasty,
* age 20-85 year old,
* accepted and sign informed consent,

Exclusion Criteria

* unstable coronary artery disease,
* indications for a coronary artery bypass graft (CABG),
* peripheral artery disease,
* uncontrolled arterial hypertension,
* ventricular and supraventricular arrhythmias in excess of 10% of all the evolutions throughout the day,
* allergy to latex,
* deformities or condition after the amputation of fingers,
* body mass index (BMI) above 35 kg/m2,
* a significant hepatic or renal failure,
* infectious disease.

Minimum Eligible Age

20 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No