Vascular Endothelial Growth Factor and Endostatin in Angiogenesis After Acute Ischemic Stroke

NCT ID: NCT02157896

Last Updated: 2020-08-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-05-31

Study Completion Date

2014-05-31

Brief Summary

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Vascular endothelial growth factor (VEGF) and Endostatin (ES) participate angiogenesis after cerebral ischemia. Circulating endothelial progenitor cells (EPCs) also play a crucial role in neovascularization and tissue repair after acute ischemic stroke (AIS). The investigators sought to compare the expression of VEGF and ES in serum and the circulating EPCs in patients after AIS with that of healthy control subjects. The investigators obtained peripheral blood and serum samples from study subjects. EPCs in blood samples from AIS patients and healthy controls were quantified by flow cytometry 1 day, 3 days, 5 days and 7 days after AIS. VEGF and ES were measured by enzyme linked immunosorbent assay at the same time points. The relation between them and the relation of them to prognosis of such patients with acute ischemic stroke were assessed.

Detailed Description

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Conditions

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Acute Ischemic Stroke

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Acute ischemic stroke

Patients who suffered from acute ischemic stroke within 12 hours for the first time before entry into the study, and had a score between 6 and 25 on the National Institutes of Health Stroke Scale (NIHSS).

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of acute ischemic stroke
* Admission within 12 hours
* National Institutes of Health Stroke Scale score 6-25

Exclusion Criteria

* Lacunar infarction
* Cerebral hemorrhagic infarction
* Epilepsy or epileptic persons
* History of neurological diseases, myocardial infarction, renal and hepatic abnormalities and metabolic diseases
* Contraindications to antiplatelet treatments
* Died within the first week of hospitalization
* Serial blood samples could not be obtained
Minimum Eligible Age

45 Years

Maximum Eligible Age

74 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shanghai 6th People's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Hao Chen

Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Lixia Xue, M.D., Ph.D.

Role: STUDY_DIRECTOR

Shanghai 6th People's Hospital

Locations

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Shanghai Sixth People's Hospital

Shanghai, , China

Site Status

Countries

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China

Other Identifiers

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H1583-660110

Identifier Type: -

Identifier Source: org_study_id

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