A Non-Interventional Clinical Study to Evaluate Long-Term Safety and Effectiveness of HUMIRA (Adalimumab) in Pediatric Patients With Moderately to Severely Active Crohn's Disease (CD)

NCT ID: NCT02130362

Last Updated: 2025-07-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

1446 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-08-28

Study Completion Date

2030-11-30

Brief Summary

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This is a registry study to evaluate the long-term safety and effectiveness of adalimumab in pediatric patients with moderately to severely active CD who are treated as recommended in the local product label.

Detailed Description

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Conditions

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Crohn's Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Immunosuppressant Therapy

Pediatric patients who are being prescribed and treated with immunosuppressant therapy

No interventions assigned to this group

Adalimumab (Humira) Treatment

Pediatric patients who are prescribed and treated with adalimumab

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* For a patient enrolling into the HUMIRA treatment group; A pediatric patient between the ages of 6 and 17 years inclusive at the time of enrollment, diagnosed with moderately to severely active CD who has been prescribed Humira therapy according to the routine clinical practice.
* For a patient enrolling into the immunosuppressant therapy treatment group; A pediatric patient between the ages of 6 and 17 years inclusive at the time of enrollment, diagnosed with moderately to severely active CD who has been prescribed azathioprine, 6-mercaptopurine or methotrexate.
* Parent or guardian; or patient (if 18 years of age or older at enrollment and rolling over from an AbbVie-sponsored investigational Pediatric CD investigation trial) has voluntarily signed and dated an Authorization for Use/Disclosure of Data (AUDD)/informed consent form (ICF) after the nature of the registry has been explained and the patient, patient's parent or legal guardian has had the opportunity to ask questions.

Exclusion Criteria

* Patients should not be enrolled into the registry if they are currently being treated with any investigational agents or are receiving any investigational procedures.
* Patients should not be enrolled into the immunosuppressant therapy treatment group if they require ongoing treatment with approved biologic agents including HUMIRA.
Minimum Eligible Age

6 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AbbVie

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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ABBVIE INC.

Role: STUDY_DIRECTOR

AbbVie

Locations

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Univ Alabama, Birmingham CCC /ID# 146060

Birmingham, Alabama, United States

Site Status

University of South Alabama /ID# 137255

Mobile, Alabama, United States

Site Status

Phoenix Children's Hospital /ID# 141336

Phoenix, Arizona, United States

Site Status

Children's Hospital Los Angeles /ID# 141551

Los Angeles, California, United States

Site Status

Private practice: Dr. Shervin Rabizadeh /ID# 137269

Los Angeles, California, United States

Site Status

Rady Children's Hospital San Diego /ID# 140883

San Diego, California, United States

Site Status

Univ California, San Francisco /ID# 141312

San Francisco, California, United States

Site Status

Children's Hospital Colorado - Aurora /ID# 137261

Aurora, Colorado, United States

Site Status

Connecticut Children's Medical Center - Hartford /ID# 137265

Hartford, Connecticut, United States

Site Status

Yale University School of Medicine /ID# 137257

New Haven, Connecticut, United States

Site Status

Nemours Children's Health System /ID# 148498

Jacksonville, Florida, United States

Site Status

University of Miami /ID# 140893

Miami, Florida, United States

Site Status

Winship Cancer Institute of Emory University /ID# 144274

Atlanta, Georgia, United States

Site Status

Children's Ctr Digestive, US /ID# 144625

Atlanta, Georgia, United States

Site Status

Children's Hospital New Orleans /ID# 144477

New Orleans, Louisiana, United States

Site Status

Maine Medical Partners /ID# 147685

Portland, Maine, United States

Site Status

Tufts Medical Center /ID# 143581

Boston, Massachusetts, United States

Site Status

Massachusetts General Hospital /ID# 141552

Boston, Massachusetts, United States

Site Status

Boston Children's Hospital /ID# 164102

Boston, Massachusetts, United States

Site Status

Duplicate_UMass Chan Medical School /ID# 148325

Worcester, Massachusetts, United States

Site Status

M Health Fairview University of Minnesota Medical Center - East Bank /ID# 137238

Minneapolis, Minnesota, United States

Site Status

Mayo Clinic - Rochester /ID# 149245

Rochester, Minnesota, United States

Site Status

Univ of Mississippi Med Ctr,US /ID# 137239

Jackson, Mississippi, United States

Site Status

Goryeb Children's Hospital /ID# 144275

Morristown, New Jersey, United States

Site Status

Women and Childrens Hosp /ID# 143778

Buffalo, New York, United States

Site Status

CCMC - Steven and Alexandra Cohen Children's Medical Center of New York /ID# 137266

New Hyde Park, New York, United States

Site Status

Columbia Univ Medical Center /ID# 144440

New York, New York, United States

Site Status

Columbia Univ Medical Center /ID# 144475

New York, New York, United States

Site Status

Univ Med Ctr at Stony Brook /ID# 140913

Stony Brook, New York, United States

Site Status

SUNY Upstate Medical University /ID# 148437

Syracuse, New York, United States

Site Status

Univ NC Chapel Hill /ID# 137236

Chapel Hill, North Carolina, United States

Site Status

Duke Cancer Center /ID# 137268

Durham, North Carolina, United States

Site Status

Children's Hospital Oklahoma /ID# 144047

Oklahoma City, Oklahoma, United States

Site Status

Geisinger Medical Center /ID# 149910

Danville, Pennsylvania, United States

Site Status

Penn State Child Hosp.Hersh,PA /ID# 144476

Hershey, Pennsylvania, United States

Site Status

Duplicate_Medical University of South Carolina /ID# 144473

Charleston, South Carolina, United States

Site Status

Children's Medical Center /ID# 149256

Dallas, Texas, United States

Site Status

Cook Children's Med. Center /ID# 144474

Fort Worth, Texas, United States

Site Status

Texas Children's Hospital /ID# 148211

Houston, Texas, United States

Site Status

University Of Vermont Medical /ID# 137263

Burlington, Vermont, United States

Site Status

Pediatric Specialty of VA /ID# 142831

Fairfax, Virginia, United States

Site Status

Duplicate_Swedish Medical Center /ID# 137258

Seattle, Washington, United States

Site Status

Seattle Children's Hospital /ID# 140879

Seattle, Washington, United States

Site Status

MultiCare Institute for Research & Innovation /ID# 152120

Tacoma, Washington, United States

Site Status

Children's Hospital Wisconsin - Milwaukee Campus /ID# 137259

Milwaukee, Wisconsin, United States

Site Status

University Clinical Center Tuzla /ID# 130638

Tuzla, Tuzlanski, Bosnia and Herzegovina

Site Status

SHAT Hematologic Diseases /ID# 143572

Sofia, , Bulgaria

Site Status

Alberta Health Services /ID# 128717

Edmonton, Alberta, Canada

Site Status

Duplicate_University of Manitoba / Health Scuience Centre / John Buhler Research /ID# 141310

Winnipeg, Manitoba, Canada

Site Status

IWK Health Center /ID# 127912

Halifax, Nova Scotia, Canada

Site Status

The Univ of Western Ontario /ID# 137962

London, Ontario, Canada

Site Status

Hospital for Sick Children /ID# 127910

Toronto, Ontario, Canada

Site Status

Klinicki bolnicki centar Sestre milosrdnice /ID# 128256

Zagreb, City of Zagreb, Croatia

Site Status

Zadar General Hospital /ID# 129830

Zadar, , Croatia

Site Status

Fakultní nemocnice Hradec Králové - Sokolská /ID# 128521

Hradec Králové, Hradec Kralove, Czechia

Site Status

Fakultni Nemocnice Ostrava /ID# 127913

Ostrava, Ostrava-mesto, Czechia

Site Status

Fakultni nemocnice Olomouc /ID# 127437

Olomouc, , Czechia

Site Status

Fakultni nemocnice Kralovske Vinohrady /ID# 127697

Prague, , Czechia

Site Status

Krajska zdravotni a.s. Masarykova nemocnice v Usti nad Labem o.z. /ID# 129829

Ústí nad Labem, , Czechia

Site Status

Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 146013

Hvidovre, Capital Region, Denmark

Site Status

Tallinn Children's Hospital /ID# 126974

Tallinn, Harju, Estonia

Site Status

Children's Clinic Of Tartu Uni /ID# 146017

Tartu, Tartu, Estonia

Site Status

Duplicate_Hôpital Pierre Wertheimer /ID# 128193

Bron, Rhone, France

Site Status

AP-HP - Hopital Necker /ID# 147702

Paris, , France

Site Status

Universitaetsklinikum Ulm /ID# 148444

Ulm, Baden-Wurttemberg, Germany

Site Status

Duplicate_Universitaetsklinikum Erlangen /ID# 137274

Erlangen, Bavaria, Germany

Site Status

Duplicate_Universitaetsklinikum Muenster /ID# 148441

Munster, Lower Saxony, Germany

Site Status

Christliches Kinderhospital Osnabrueck /ID# 136629

Osnabrück, Lower Saxony, Germany

Site Status

Universitaetsklinikum Aachen /ID# 126591

Aachen, North Rhine-Westphalia, Germany

Site Status

Duplicate_Universitaetsklinikum Carl Gustav Carus an der TU Dresden /ID# 127696

Dresden, Saxony, Germany

Site Status

Froehlich Gemeinschaftspraxis /ID# 127975

Forchheim, , Germany

Site Status

Duplicate_Universitaetsklinikum Freiburg /ID# 130010

Freiburg im Breisgau, , Germany

Site Status

Kinderarztpraxis Neuhausen /ID# 144402

Munich, , Germany

Site Status

Universitaetsklinikum Regensburg /ID# 137140

Regensburg, , Germany

Site Status

Agia Sofia Hospital /ID# 134349

Athens, Attica, Greece

Site Status

General Hospital of Chest Diseases of Athens SOTIRIA /ID# 147690

Athens, Attica, Greece

Site Status

Iatriko Kentro Athinon /ID# 130639

Marousi, Attica, Greece

Site Status

Venizeleio General Hospital /ID# 147335

Heraklion, , Greece

Site Status

General Hospital of Thessaloniki Gennimatas /Id# 163658

Thessaloniki, , Greece

Site Status

Our Lady's Hospital /ID# 127438

Manorhamilton, Leitrim, Ireland

Site Status

Schneider Children's Medical Center /ID# 152683

Petah Tikva, Central District, Israel

Site Status

Duplicate_Kaplan Medical Center /ID# 152945

Rehovot, Central District, Israel

Site Status

Yitzhak Shamir Medical Center /ID# 157182

Ẕerifin, Central District, Israel

Site Status

Shaare Zedek Medical Center /ID# 144277

Jerusalem, Jerusalem, Israel

Site Status

Edmond And Lily Safra Children /ID# 148730

Ramat Gan, Tel Aviv, Israel

Site Status

Duplicate_Ha'Emek Medical Center /ID# 156316

Afula, , Israel

Site Status

Rambam Health Care Campus /ID# 162061

Haifa, , Israel

Site Status

The Lady Davis Carmel Medical Center /ID# 151519

Haifa, , Israel

Site Status

ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 144279

Milan, Milano, Italy

Site Status

Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 141962

Rome, Roma, Italy

Site Status

Ospedale Maggiore Carlo Alberto Pizzardi /ID# 147347

Bologna, , Italy

Site Status

Duplicate_A.O.U. Policlinico G. Martino /ID# 141683

Messina, , Italy

Site Status

ASST Fatebenefratelli Sacco/Ospedale dei Bambini Vittore Buzzi /ID# 141679

Milan, , Italy

Site Status

Duplicate_Universita di Napoli Federico II /ID# 144280

Naples, , Italy

Site Status

Duplicate_POLICLINICO PAOLO GIACCONE /ID# 138410

Palermo, , Italy

Site Status

Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 152684

Palermo, , Italy

Site Status

Azienda Ospedaliero-Universitaria di Parma /ID# 147441

Parma, , Italy

Site Status

Azienda Usl Di Pescara - Presidio Ospedaliero Di Pescara /ID# 141307

Pescara, , Italy

Site Status

Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 127809

Kaunas, , Lithuania

Site Status

Vilnius University Hospital Santaros Klinikos /ID# 127810

Vilnius, , Lithuania

Site Status

Duplicate_Academisch Medisch Centrum /ID# 141843

Amsterdam, North Holland, Netherlands

Site Status

Duplicate_Erasmus Medisch Centrum /ID# 141841

Rotterdam, South Holland, Netherlands

Site Status

2CA-Braga, Hospital de Braga /ID# 138269

Braga, , Portugal

Site Status

Unidade Local de Saude Sao Joao, EPE /ID# 138146

Porto, , Portugal

Site Status

Ctr. Gastroenterologia Ped Oes /ID# 140875

Mayagüez, , Puerto Rico

Site Status

San Jorge Children Hospital /ID# 138067

San Juan, , Puerto Rico

Site Status

Spitalul Clinic de Urgenta pentru Copii- Pediatrie II-Nefrologie Pediatrica /ID# 131297

Cluj-Napoca, Cluj, Romania

Site Status

Spitalul Clinic de Urgenta pentru Copii ?Louis Turcanu? /ID# 130251

Timișoara, Timiș County, Romania

Site Status

Spitalul Clinic de Urgenta Pentru Copii Grigore Alexandrescu /Id# 130358

Bucharest, , Romania

Site Status

Spitalul Clinic Judetean de Urgenta Targu Mures /ID# 137014

Târgu Mureş, , Romania

Site Status

Complejo Hospitalario Universitario A Coruña /ID# 137235

A Coruña, A Coruna, Spain

Site Status

Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 138462

Ferrol, A Coruna, Spain

Site Status

Complejo Hospitalario Universitario de Santiago (CHUS) /ID# 141667

Santiago de Compostela, A Coruna, Spain

Site Status

Hospital Universitari Son Espases /ID# 147446

Palma de Mallorca, Balearic Islands, Spain

Site Status

Hospital Universitario Germans Trias i Pujol /ID# 139400

Badalona, Barcelona, Spain

Site Status

Hospital Sant Joan de Deu /ID# 152059

Esplugues de Llobregat, Barcelona, Spain

Site Status

Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 149029

Sabadell, Barcelona, Spain

Site Status

Hospital Universitario Severo Ochoa /ID# 141545

Leganés, Madrid, Spain

Site Status

Hospital Universitario Puerta de Hierro - Majadahonda /ID# 157872

Majadahonda, Madrid, Spain

Site Status

Hospital Clinico Universitario Virgen de la Arrixaca /ID# 138460

El Palmar, Murcia, Spain

Site Status

Hospital Universitario Central de Asturias /ID# 163053

Oviedo, Principality of Asturias, Spain

Site Status

OSI Ezkerraldea-Enkarterri-Cruces /ID# 141781

Barakaldo, Vizcaya, Spain

Site Status

Hospital Universitario Vall d'Hebron /ID# 141778

Barcelona, , Spain

Site Status

Hospital Universitario Vall d'Hebron /ID# 146015

Barcelona, , Spain

Site Status

Hospital General de Granollers /ID# 140882

Barcelona, , Spain

Site Status

Hospital Universitario de Girona Doctor Josep Trueta /ID# 147572

Girona, , Spain

Site Status

Hospital Infantil Universitario Nino Jesus /ID# 165738

Madrid, , Spain

Site Status

Hospital Universitario 12 de Octubre /ID# 136998

Madrid, , Spain

Site Status

Hospital Universitario La Paz /ID# 161152

Madrid, , Spain

Site Status

Hospital Regional Universitario de Malaga /ID# 144289

Málaga, , Spain

Site Status

Compl Hospital Univer de Vigo /ID# 136999

Pontevedra, , Spain

Site Status

Hospital Universitario Dr. Peset /ID# 159484

Valencia, , Spain

Site Status

Hospital Universitario y Politecnico La Fe /ID# 141847

Valencia, , Spain

Site Status

Karolinska University Hospital Solna /ID# 129045

Solna, Stockholm County, Sweden

Site Status

Sodersjukhuset /ID# 152685

Stockholm, Stockholm County, Sweden

Site Status

University Hospital of Derby and Burton NHS Foundation Trust /ID# 131592

Derby, Derbyshire, United Kingdom

Site Status

Sheffield Children's Hospital NHS Foundation Trust /ID# 130370

Sheffield, England, United Kingdom

Site Status

Disc_Barts Health NHS Trust - The Royal London Hospital /ID# 128471

London, Greater London, United Kingdom

Site Status

University Hospital Southampton NHS Foundation Trust /ID# 147538

Southampton, Hampshire, United Kingdom

Site Status

Duplicate_NHS Greater Glasgow and Clyde /ID# 127436

Glasgow, Scotland, United Kingdom

Site Status

St Helier Hospital /ID# 150097

Carshalton, Surrey, United Kingdom

Site Status

NHS Grampian /ID# 131296

Aberdeen, , United Kingdom

Site Status

Birmingham Women's and Children's NHS Foundation Trust /ID# 136631

Birmingham, , United Kingdom

Site Status

Duplicate_Cambridge University Hospitals NHS Foundation Trust /ID# 143779

Cambridge, , United Kingdom

Site Status

Alder Hey Children's Hospital /ID# 138013

Liverpool, , United Kingdom

Site Status

Manchester University NHS Foundation Trust /ID# 128476

Manchester, , United Kingdom

Site Status

Duplicate_The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 147438

Newcastle upon Tyne, , United Kingdom

Site Status

St George's University Hospitals NHS Foundation Trust /ID# 131590

Tooting, , United Kingdom

Site Status

Countries

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United States Bosnia and Herzegovina Bulgaria Canada Croatia Czechia Denmark Estonia France Germany Greece Ireland Israel Italy Lithuania Netherlands Portugal Puerto Rico Romania Spain Sweden United Kingdom

Related Links

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Other Identifiers

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P11-292

Identifier Type: -

Identifier Source: org_study_id

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