A Study to Assess Safety and Effectiveness of Adalimumab for Treating Children and Adolescents With Crohn's Disease in Real Life Conditions

NCT ID: NCT03017014

Last Updated: 2020-10-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

62 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-09-26

Study Completion Date

2019-10-14

Brief Summary

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The primary objective of this study is to evaluate long-term effectiveness of adalimumab in pediatric participants starting a treatment for Crohn's disease in real life conditions, namely to describe the time to loss of clinical benefit in a time to event approach. Main secondary objectives are to describe growth and pubertal development and to describe long-term safety. The participants will be followed-up up to 10 years.

Detailed Description

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Conditions

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Crohn's Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Pediatric participants receiving adalimumab

Pediatric participants receiving adalimumab for CD in real-life conditions.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* With confirmed diagnosis of Crohn's disease
* Adalimumab-naïve patient (a patient having received an anti-TNF other than adalimumab may enter the study)
* Starting a treatment with adalimumab
* Guardian capable of and willing to grant authorization for use/disclosure of data collected and patient able to comply with the requirements of the study protocol.

Exclusion Criteria

* Participants with a history of treatment with adalimumab
* Participants enrolled in a concomitant interventional clinical trial.
Minimum Eligible Age

6 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AbbVie

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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AbbVie Inc.

Role: STUDY_DIRECTOR

AbbVie

Locations

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Centre Hospitalier Lyon Sud /ID# 152667

Pierre-Bénite, Auvergne-Rhône-Alpes, France

Site Status

Centre Hospitalier Lyon Sud /ID# 152668

Pierre-Bénite, Auvergne-Rhône-Alpes, France

Site Status

Hopital Clocheville /ID# 152831

Tours, Centre-Val de Loire, France

Site Status

CHU de Besancon - Jean Minjoz /ID# 154197

Besançon, Doubs, France

Site Status

Hopitaux de Brabois Adultes /ID# 152729

Vandœuvre-lès-Nancy, Lorraine, France

Site Status

CHU Toulouse /ID# 153251

Toulouse, Occitanie, France

Site Status

CHU Batiment Robert Debre /ID# 152665

Angers, , France

Site Status

CHU Bordeaux-Hopital Pellegrin /ID# 154620

Bordeaux, , France

Site Status

Chu de Bordeaux Hopital /Id# 157926

Bordeaux, , France

Site Status

Centre Hospitalier Universitai /ID# 155465

Caen, , France

Site Status

CHU Hopital d'Estaing /ID# 152664

Clermont-Ferrand, , France

Site Status

Hopital Jeanne de Flandre /Id# 155464

Lille, , France

Site Status

Hopital de la Timone /ID# 160133

Marseille, , France

Site Status

Hopital Jacques Monod /ID# 152663

Montivillier, , France

Site Status

Hopital de la Source /ID# 159947

Orléans, , France

Site Status

Hopital de la Source /ID# 165534

Orléans, , France

Site Status

Robert Debre Hopital, FR /ID# 152666

Paris, , France

Site Status

Hopital Armand Trousseau /Id# 152669

Paris, , France

Site Status

Hopital Armand Trousseau /Id# 157092

Paris, , France

Site Status

Necker Hopital, FR /ID# 152830

Paris, , France

Site Status

Chu Lyon Sud /Id# 152838

Pierre-Bénite, , France

Site Status

CHU de Rennes - Hospital Sud /ID# 152730

Rennes, , France

Site Status

Charles Nicolle Hosp chu rouen /ID# 152670

Rouen, , France

Site Status

Charles Nicolle Hosp chu rouen /ID# 158688

Rouen, , France

Site Status

Countries

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France

Related Links

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Other Identifiers

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P15-759

Identifier Type: -

Identifier Source: org_study_id

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