Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
75 participants
INTERVENTIONAL
2011-06-30
2015-12-31
Brief Summary
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Volumetric Modulated Arc Therapy (VMAT or Arc Radiotherapy) is a novel method of delivering radiotherapy that involves the continuous movement of the radiotherapy treatment machine head around the patient and MLC during radiation. Arc radiotherapy has been clinically implemented at The Christie for prostate radiotherapy treatments and work is in progress for implementation in lung radiotherapy. The continuous gantry rotation inherent to VMAT delivery makes this simultaneous imaging possible, although there are concerns associated with the impact that this may have on patient dose and image quality.
The aim of this research is to assess whether the image quality of cone beam scans taken during treatment are as good as standard cone beam scans taken before or after treatment used to determine the accuracy of patient position and the tumour coverage by radiotherapy.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
NONE
Study Groups
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Cone Beam Computed Tomography
Simultaneous Cone Beam Computed Tomography acquisition during arc radiotherapy.
Cone Beam Computed Tomography
Simultaneous Cone Beam Computed Tomography acquisition during arc radiotherapy
Interventions
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Cone Beam Computed Tomography
Simultaneous Cone Beam Computed Tomography acquisition during arc radiotherapy
Eligibility Criteria
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Inclusion Criteria
* Patients to be treated with VMAT
* ECOG performance status 0-2
* Patients must be able to receive and understand verbal and written information regarding the study and give written, informed consent
* A histological or cytological diagnosis of non-small cell lung cancer or small cell lung cancer
* Patients to be treated with radical RT or SBRT
* Patients to be treated with VMAT
* ECOG performance status 0-2
* Patients must be able to receive and understand verbal and written information regarding the study and give written, informed consent
* Female patients must meet one of the following criteria - postmenopausal for a minimum of one year, surgically sterile, not pregnant, confirmed by β-HCG blood test and willing to use adequate contraception during study participation, not breastfeeding
Exclusion Criteria
* Patients in clinical trials of new investigational medicinal products or treatment regimens unless there is written, prior agreement that the patient can also consent to this study, and that clinical data can also be used for this study
* Prior radiotherapy or surgery in the pelvis that can make identification of normal anatomy difficult
* Clinical judgement by the investigator that the patient should not participate in the study
* Patients in clinical trials of new investigational medicinal products or treatment regimens unless there is written, prior agreement that the patient can also consent to this study, and that clinical data can also be used for this study
* Prior radiotherapy or surgery in the region of interest that can make identification of normal anatomy difficult
18 Years
ALL
No
Sponsors
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Sally Falk
OTHER
Responsible Party
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Sally Falk
Clinical Trial Project Manager
Principal Investigators
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Corinne Faivre-Finn, MD PhD
Role: PRINCIPAL_INVESTIGATOR
The Christie NHS Foundation Trust
Ananya Choudhury
Role: PRINCIPAL_INVESTIGATOR
The Christie NHS Foundation Trust
Locations
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The Christie NHS Foundation Trust
Manchester, Greater Manchester, United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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10_RADIO_94
Identifier Type: -
Identifier Source: org_study_id
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