Feasibility of VMAT and CBCT for Head and Neck Carcinomas

NCT ID: NCT01384890

Last Updated: 2013-02-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-07-31

Study Completion Date

2012-05-31

Brief Summary

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This will be a prospective longitudinal study describing clinical throughput metrics and patient reported quality of life outcome measures for patients undergoing Volumetric modulated arc therapy (VMAT) with and without Cone-beam computed tomography (CBCT) for head and neck carcinoma at the British Columbia Cancer Agency.

1. VMAT for the treatment of patients with HNC will provide opportunities for image-guided radiotherapy using CBCT online correction to reduce systematic and random error.
2. Analysis of patient reported quality of life outcomes during VMAT, with and without CBCT acquisition, will be hypothesis generating.

Detailed Description

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Conditions

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Head and Neck Carcinoma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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VMAT with CBCT

Volumetric modulated arc therapy (VMAT) with cone-beam computed tomography position (CBCT) verification

Group Type EXPERIMENTAL

VMAT with CBCT

Intervention Type RADIATION

volumetric modulated arc therapy (VMAT) with cone-beam computed tomography (CBCT) position verification

VMAT with kV-ray

Volumetric modulation arc therapy (VMAT) with kV-ray position verification

Group Type ACTIVE_COMPARATOR

VMAT with kV-ray

Intervention Type RADIATION

Volumetric modulated arc therapy (VMAT) with kV-ray position verification

Interventions

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VMAT with CBCT

volumetric modulated arc therapy (VMAT) with cone-beam computed tomography (CBCT) position verification

Intervention Type RADIATION

VMAT with kV-ray

Volumetric modulated arc therapy (VMAT) with kV-ray position verification

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* age greater than 18 years
* undergoing radical radiation therapy for head and neck carcinoma at the BC Cancer Agency

Exclusion Criteria

* treatment being offered is not for curative intent
* patient has received previous radiation for head and neck cancer
* patient has systemic lupus erythematosis or scleroderma
* patients has other autoimmune connective tissue disorders
Minimum Eligible Age

18 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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British Columbia Cancer Agency

OTHER

Sponsor Role lead

Responsible Party

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Jonn Wu

Dr. Jonn Wu

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jonn Wu, MD

Role: PRINCIPAL_INVESTIGATOR

British Columbia Cancer Agency

Locations

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BC Cancer Agency - Vancouver Centre

Vancouver, British Columbia, Canada

Site Status

Countries

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Canada

Other Identifiers

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VMAT, CBCT for H&N ca

Identifier Type: -

Identifier Source: org_study_id

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