A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
NCT ID: NCT02118922
Last Updated: 2025-11-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
168 participants
OBSERVATIONAL
2013-06-30
2026-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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Healthy volunteers
Volunteers with normal corneas
Brillouin imaging
Patients with keratoconus
Patients diagnosed with keratoconus
Brillouin imaging
post-LASIK no complications
Subjects who underwent LASIK refractive surgery with no complications
Brillouin imaging
post-LASIK who developed ectasia
patients who underwent LASIK refractive surgery and developed ectasia as a complications
Brillouin imaging
Volunteers to receive PRK surgery
This group includes patients who have been diagnosed with myopia and have been scheduled to undergo PRK surgery. Patients with high astigmatism \> 2 diopter, prior ocular surgeries, and those patients taking any ocular medications except seasonal allergy medicine such as ketotifen or artificial tears will be excluded.
Brillouin imaging
Volunteers to receive LASIK Surgery
This group includes myopic patients who are scheduled to receive LASIK surgery. Patients with high astigmatism \> 2 diopter, prior ocular surgeries, and those patients taking any ocular medications except seasonal allergy medicine such as ketotifen and artificial tears will be excluded.
Brillouin imaging
Patients with Fuch's Endothelial Corneal Dystrophy
This group includes subjects who are diagnosed with Fuch's corneal dystrophy, at early, mild and advanced stages. The inclusion also extends to subjects with, and without keratoconus. But this exclude patients with any other corneal disorders other than keratoconus, and/or history of ophthalmological surgeries that may affect endothelium cell status, e.g. cataract surgeries.
Brillouin imaging
Interventions
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Brillouin imaging
Eligibility Criteria
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Exclusion Criteria
* Monocular subjects
* Do not or cannot understand the instructions for the imaging
20 Years
75 Years
ALL
Yes
Sponsors
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Harvard Medical School (HMS and HSDM)
OTHER
Massachusetts General Hospital
OTHER
Responsible Party
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Seok Hyun Yun
Associate Professor
Principal Investigators
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Andy Yun, PhD
Role: PRINCIPAL_INVESTIGATOR
Masachusetts General Hospital
Locations
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Massachusetts General Hospital
Boston, Massachusetts, United States
Countries
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Central Contacts
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Facility Contacts
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References
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Scarcelli G, Kling S, Quijano E, Pineda R, Marcos S, Yun SH. Brillouin microscopy of collagen crosslinking: noncontact depth-dependent analysis of corneal elastic modulus. Invest Ophthalmol Vis Sci. 2013 Feb 19;54(2):1418-25. doi: 10.1167/iovs.12-11387.
Scarcelli G, Yun SH. In vivo Brillouin optical microscopy of the human eye. Opt Express. 2012 Apr 9;20(8):9197-202. doi: 10.1364/OE.20.009197.
Scarcelli G, Pineda R, Yun SH. Brillouin optical microscopy for corneal biomechanics. Invest Ophthalmol Vis Sci. 2012 Jan 20;53(1):185-90. doi: 10.1167/iovs.11-8281.
Scarcelli G, Yun SH. Confocal Brillouin microscopy for three-dimensional mechanical imaging. Nat Photonics. 2007 Dec 9;2:39-43. doi: 10.1038/nphoton.2007.250.
Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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2012P002178
Identifier Type: -
Identifier Source: org_study_id
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