Exercise and Repetitive Diving

NCT ID: NCT02118207

Last Updated: 2014-04-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-10-31

Study Completion Date

2014-01-31

Brief Summary

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SCUBA diving frequently involves repetitive exposures over multiple days. The goal of this study was to see how exercise impacts microparticles (MPs), endothelial function, and venous gas emboli (VGE) over a series of dives.

16 divers in 2 groups each completed 6 dives. One group completed 3 control dives followed by 5 days rest then 3 dives preceded by exercise. The other group completed the opposite protocol. Flow-mediated dilation (FMD) data and blood for MP analysis was collected before and after each dive. VGE were monitored via transthoracic echocardiography 30, 60, and 90 min after surfacing. Exercise before diving consisted of 60 min running outdoors including 8x4 min intervals at 90% VO2max effort.

Detailed Description

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Conditions

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Decompression Sickness Endothelial Dysfunction Neutrophil Activation Venous Gas Emboli

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Control dives 1st

Subjects in this group complete the first 3 dives as control dives and the second 3 dives preceded by aerobic exercise

Group Type EXPERIMENTAL

Aerobic running exercise

Intervention Type OTHER

60 min of aerobic intervals completed prior to SCUBA diving

Predive exercise 1st

Subjects complete the first 3 dives preceded by the intervention of aerobic exercise and the second 3 with no exercise as control dives

Group Type EXPERIMENTAL

Aerobic running exercise

Intervention Type OTHER

60 min of aerobic intervals completed prior to SCUBA diving

Interventions

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Aerobic running exercise

60 min of aerobic intervals completed prior to SCUBA diving

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Certified SCUBA diver
* Certified to dive by experienced Medical evaluator
* Must be able to run continuously for 45 min

Exclusion Criteria

* Prior diagnosis of decompression sickness
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Maryland

OTHER

Sponsor Role collaborator

University Hospital of Split

OTHER

Sponsor Role lead

Responsible Party

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Zeljko Dujic

Professor Zeljko Dujic MD, PhD, Director of Department of Physiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Zeljko Dujic, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Split, School of Medicine

Locations

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University of Maryland

Baltimore, Maryland, United States

Site Status

University of Split School of Medicine

Split, , Croatia

Site Status

Countries

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United States Croatia

Other Identifiers

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264816-02

Identifier Type: -

Identifier Source: org_study_id

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