Effect of Transcutaneous Nerve Stimulation on Primary Motor Cortex to Modulate Cortical Excitability and Hemodynamic Response During Implicit Motor Learning: A TMS and NIRS Study

NCT ID: NCT02115841

Last Updated: 2014-04-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-08-31

Study Completion Date

2014-07-31

Brief Summary

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Noninvasive brain stimulation was recently gradually be emphasized. The electrical current applied on scalp can effective modulate cortical excitability. Forms of Stimulation included transcranial direct current stimulation(tDCS) and transcranial alternating stimulation(tACS). tDCS had been proved the effect of cortical excitability modulation. The polarization effect of direct current stimulation can modulation specific brain area and enhance motor performance. tACS was still controversial about the effect on cortical excitability. Previous study show that the frequency dependent excitatory or inhibitory effect on cortex. The possible mechanism was to affect brain oscillation status by provided different frequency of stimulation. Transcutaneous nerve stimulation (TENS) was common used on management of chronic pain. Peripheral nerve stimulation can enhance pain or sensory evoked potential was noted. Effect of low frequency TENS on central nervous is unknown.

Detailed Description

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Conditions

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Transcutaneous Nerve Stimulation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

SINGLE

Participants

Study Groups

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E1

Experiment 1 will measure the cortical excitability change after TENS intervention.

Group Type EXPERIMENTAL

"Enraf-Nonius" Muscle stimulator

Intervention Type DEVICE

The order 15Hz TENS stimulation session and sham stimulation session will also be randomized.

E2

Experiment 2 will measures implicit sequential motor task performance and cortical hemodynamic response using near infrared spectroscopy (NIRS) during motor execution. Cortical excitability will also be measured contemporary

Group Type EXPERIMENTAL

"Enraf-Nonius" Muscle stimulator

Intervention Type DEVICE

The order 15Hz TENS stimulation session and sham stimulation session will also be randomized.

Interventions

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"Enraf-Nonius" Muscle stimulator

The order 15Hz TENS stimulation session and sham stimulation session will also be randomized.

Intervention Type DEVICE

Other Intervention Names

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Transcutaneous nerve stimulation

Eligibility Criteria

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Inclusion Criteria

* Health Adult
Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Chang Gung University

OTHER

Sponsor Role lead

Responsible Party

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Ya-Ju Chang

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Chang Gung University

Taoyuan District, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Facility Contacts

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Ya-Ju Chang, PhD

Role: primary

88632118800 ext. 5515

Other Identifiers

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102-2266A3

Identifier Type: -

Identifier Source: org_study_id

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