Association Between Basal Proteinuria Levels and Pregnancy Outcomes in Familial Mediterranean Fever
NCT ID: NCT02092064
Last Updated: 2014-03-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
40 participants
OBSERVATIONAL
2014-04-30
2015-04-30
Brief Summary
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Detailed Description
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The diagnosis of FMF may be extremely difficult to establish in the presence of atypical signs, and absence of family history . Colchicine is effective in most of the patients with FMF. The one the most important complications of FMF is the development of renal amyloidosis. It potentially progress sequentially through preclinical, proteinuric, nephrotic, azotemic and uremic stages to end stage renal disease if not treated properly with colchicine. Previous studies suggests that colchicine does not appear to be a major human teratogen, and, probably, has no cytogenetic effect.
FMF affects females mainly in their childbearing years. FMF is associated with higher rates of recurrent abortion, premature rupture of membranes (PROM) and preterm birth. Despite of adverse outcomes have been reported in pregnants with FMF the outcome of pregnancies in FMF appear favorable with the healthy population since the usingof the colchicine. Although the effect of pregnancy on the course of FMF related amyloidosis is controversial, it is generally accepted that renal function may disrupt during pregnancy.
Few studies have investigated the effect of FMF complications (amyloidosis and nephrotic syndrome) on pregnancy course.
The aim of this study is to investigate the effect of basal proteinuria on pregnancy outcome of patients with Familial Mediterranean fever (FMF).
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
39 Years
FEMALE
Yes
Sponsors
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Zekai Tahir Burak Women's Health Research and Education Hospital
OTHER
Responsible Party
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cantekin iskender
Perinatology
Principal Investigators
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dilek uygur
Role: PRINCIPAL_INVESTIGATOR
zekai tahir burak hospital
Locations
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Zekai Tahir Burak Maternity Hospital
Ankara, Altindag, Turkey (Türkiye)
Countries
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Central Contacts
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References
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Turgal M, Selcuk I, Ozyuncu O. Pregnancy outcome of five patients with renal amyloidosis regarding familial Mediterranean fever. Ren Fail. 2014 Mar;36(2):306-8. doi: 10.3109/0886022X.2013.846863. Epub 2013 Oct 29.
Yasar O, Iskender C, Kaymak O, Taflan Yaman S, Uygur D, Danisman N. Retrospective evaluation of pregnancy outcomes in women with familial Mediterranean fever. J Matern Fetal Neonatal Med. 2014 May;27(7):733-6. doi: 10.3109/14767058.2013.837446. Epub 2013 Sep 25.
Other Identifiers
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Basal Proteinuria in FMF
Identifier Type: -
Identifier Source: org_study_id
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