Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
50 participants
OBSERVATIONAL
2016-12-31
2017-03-31
Brief Summary
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Detailed Description
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HG was defined according to the fallowing American College of Obstetricians and Gynecologists (ACOG) criteria; severe nausea and vomiting resulted in 5% weight loss with regard to pre-gestation or vomiting more than 3 times and 3-5 % weight loss with ketonuria. The diagnosis of dehydration was clinically defined and patients with moderate and severe dehydration were included in the study. As clinical findings; Weight loss, capillary recall time, dry mucous membranes, dry eye, pulse rate, systolic blood pressure, respiration, skin turgor deterioration and urine output were evaluated.
Other pathologies causing nausea and vomiting like; gastroenteritis, gastroparesis, gall duct diseases, hepatitis, peptic ulcers, appendicitis, pyelonephritis, ovarian torsion, urinary tract stones, diabetic ketoacidosis, hyperthyroidism, hyperparathyroidism, migraine, pseudo tumor cerebra, vestibular diseases were excluded from the study.Patients were excluded from the study in the presence of pregestational diabetes chronic hypertension, chronic liver and renal failure, preeclampsia history, multiple pregnancy, hyperlipidemia, hypercholesterolemia, obesity, tobacco use, NSAID drug use, infection within the last three months and surgery within the last month that could cause endothelial dysfunction.
Blood and urine specimens were collected from the patients with HG during hospitalization and during regular clinic visits in control group. The 2mL of blood samples were withdrawn into serum-separating tubes for the measurements of serum biochemical parameters and 2 mL blood samples were withdrawn into EDTA containing tubes for measurement serum hemoglobin and hematocrit levels. Early-morning urine samples were collected from study population. These blood and urine samples were analyzed in same day for Kayseri Education and Research hospital biochemical clinics. In addition 2mL of blood samples were withdrawn into serum-separating tubes for analyzing serum sVEGFR-1, sVCAM-1, sE-selectin and sICAM-1 levels. All of the serum were stored at -80°C in nonadsorbable tubes. After three months for stored first blood sample, serum sVEGFR-1, sVCAM-1, sE-selectin and sICAM-1 levels were determined by an enzyme linked immunosorbent assay.
Conditions
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Keywords
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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hyperemesis gravidarum with dehydration
The first group was formed of the patients diagnosed hyperemesis gravidarum with dehydration
No interventions assigned to this group
Control group
The control group was formed of the patients who were healthy pregnant women admitted to the clinic just for routine examination without any symptoms
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* between 18-35 years of age
* Single pregnancy
* Dehydration due to HG
Exclusion Criteria
* gastroenteritis
* gastroparesis
* gall duct diseases
* hepatitis
* peptic ulcers
* appendicitis
* pyelonephritis
* urinary tract stones
* hyperthyroidism
* hyperparathyroidism
* migraine
* vestibular diseases
Patients were excluded from the study in the presence of parameters that may cause endothelial dysfunction such as;
* pregestational diabetes
* chronic hypertension
* chronic liver and renal failure
* preeclampsia history
* multiple pregnancy
* hyperlipidemia
* hypercholesterolemia
* obesity
* tobacco use
* NSAID drug use
* infection within the last three months
* surgery within the last month
18 Years
35 Years
FEMALE
Yes
Sponsors
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Kayseri Education and Research Hospital
OTHER_GOV
Responsible Party
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Erdem Sahin
Principal Investigator
Principal Investigators
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Erdem SAHİN
Role: PRINCIPAL_INVESTIGATOR
Kayseri Training and Research Hospital
Locations
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Kayseri Training and Research Hospital
Kayseri, , Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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yusuf madendag
Role: primary
Other Identifiers
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2016/579
Identifier Type: -
Identifier Source: org_study_id