Cerebral Abnormalities Detected by MRI, Realized at the Age of Term and the Emergence of Executive Functions

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

600 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-06-30

Study Completion Date

2017-09-30

Brief Summary

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The survival of premature babies increased during the last decades. However, the neurocognitive long term development of these children is worrying, as demonstrated by EPIPAGE 1 study.

These children present high risk of deficits such as cognitive deficits, adaptive malfunction, behavior disorders and difficulties in school learning.

Understanding the specific neuropsychological disorders at the origin of these deficits is an important objective. Studies realized at school age showed that many premature children have executive functions (EF) disorders. However the specific nature of these disorders and the neuropathology associated are unknown.

The aim of this study is to realise MRI at term age in preterm babies born less than 32 GA and to correlate MRI findings with executives functions and neurodevelopmental outcome

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Detailed Description

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An MRI would be realized between 39 and 41 GA

At the age of 5 years, executive functions and neurodevelopmental testing would be realized.

600 newborns were recruited.

Conditions

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Premature Baby 25 to 32 Weeks

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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MRI assessment

Group Type EXPERIMENTAL

term MRI, executive EF functions testing

Intervention Type PROCEDURE

An MRI will be realized at term born between 25 and 32 weeks GA

Interventions

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term MRI, executive EF functions testing

An MRI will be realized at term born between 25 and 32 weeks GA

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

Infants who were :

* born between 25 and 32 WGA
* hospitalized in a neonatology service which participate to the present study
* included in EPIPAGE 2 follow-up study
* infants whose parents had signed the consent agreement and benefit from national health insurance