Neonatal Precursors of Neurodevelopment

NCT ID: NCT04703010

Last Updated: 2022-03-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-03-01

Study Completion Date

2024-09-01

Brief Summary

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The NEOPRENE project proposes to examine processes that are among the earliest precursors of cognitive functions and assess 1) the relationship between neonatal cognitive precursors and cortical structure, structural connectivity and functional connectivity at birth and 2) the relationship between neonatal cognitive precursors and neurodevelopment.

Detailed Description

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Conditions

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Premature Birth

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Longitudinal study with measures at birth and at age 2.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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All participants

All participants undergo the same measurements (longitudinal design)

Group Type EXPERIMENTAL

Electroencephalography-Near infrared spectroscopy

Intervention Type DEVICE

Brain activity will be measured using 128-channel EEG and 2 channel NIRS during tactile stimulation (15 minutes sequence of vibrations) while the newborn is asleep.

Magnetic resonance imaging

Intervention Type DEVICE

Structural (T1-T2), siffusion tensor imaging and blood-oxygen level dependant signal will be acquired in a subset of 40 subjects (20 minutes while asleep)

Psychometric testing

Intervention Type BEHAVIORAL

Cognitive evaluation at age 2 (Parental questionnaires on sensory profiles, executive functions and neurodevelopmental disorders screening, child tests : movement assessment battery, Laby, Head-toes-shoulders-knees)

Interventions

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Electroencephalography-Near infrared spectroscopy

Brain activity will be measured using 128-channel EEG and 2 channel NIRS during tactile stimulation (15 minutes sequence of vibrations) while the newborn is asleep.

Intervention Type DEVICE

Magnetic resonance imaging

Structural (T1-T2), siffusion tensor imaging and blood-oxygen level dependant signal will be acquired in a subset of 40 subjects (20 minutes while asleep)

Intervention Type DEVICE

Psychometric testing

Cognitive evaluation at age 2 (Parental questionnaires on sensory profiles, executive functions and neurodevelopmental disorders screening, child tests : movement assessment battery, Laby, Head-toes-shoulders-knees)

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Preterm newborn (born \< 34 weeks + 6days)

Exclusion Criteria

* Brain injury
* Respiratory assistance on measurement day
* Infection on measurement day
* Sedation on measurement day
* Parents \< 18 years old or unable to give informed consent
Maximum Eligible Age

2 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Caen

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Caen University Hospital

Caen, , France

Site Status RECRUITING

Countries

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France

Facility Contacts

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Nadege Roche-Labarbe, PhD

Role: primary

33 232 568 386

Victoria Dumont, PhD

Role: backup

Related Links

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Other Identifiers

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2020-A02117-32

Identifier Type: -

Identifier Source: org_study_id

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