Gait, Stair Climbing and Postural Stability in Knee Osteoarthritis Patients After Hyaluronic Acid Injection

NCT ID: NCT02063373

Last Updated: 2014-02-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

85 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-09-30

Brief Summary

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Treatment: five intro-articular Hyaluronic Acid injection

Assessment has two parts, that are as follow:

1. Postural stability and risk of fall assessment using Biodex stability index and "Timed up and Go" test
2. Gait and stair climbing assessment using Vicon motion capture system synchronized with four force plates.

For knee OA subjects, assessment was done in week one or before injection; and for healthy controls one assessment was performed.

Detailed Description

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This study aimed to assess the effect of hyaluronic acid injection on Postural stability, biomechanics of gait and stair climbing in individuals with bilateral knee osteoarthritis (OA).

Participants were individuals with knee OA (control and treatment) and healthy people.

Conditions

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Bilateral Knee Osteoarthritis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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biomechanis knee OA and HA injection

Weekly intra- articular Hyaluronic acid injection (20 MG/ 2 ML) into both knees for five weeks

Group Type EXPERIMENTAL

Hyaluronic acid

Intervention Type OTHER

treatment: Weekly intra-articular hyaluronic acid injection (20 MG / 2ML) into both knees for five weeks.

Interventions

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Hyaluronic acid

treatment: Weekly intra-articular hyaluronic acid injection (20 MG / 2ML) into both knees for five weeks.

Intervention Type OTHER

Other Intervention Names

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Hyalgan Manufacturer: Fidia Pharmaceutici S.p.A, Italy

Eligibility Criteria

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Inclusion Criteria

* Mild and moderate bilateral knee osteoarthritis
* Age between 50 and 70 years

Exclusion Criteria

* Recent Lower limb injury
* Diabetic
* Knee or hip replacement
* Knees HA injection in last 6 months
* Any neuromuscular disease such as stroke and Parkinson
Minimum Eligible Age

50 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Malaya

OTHER

Sponsor Role lead

Responsible Party

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nafiseh khalaj

Mrs

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Khalaj N, Abu Osman NA, Mokhtar AH, George J, Abas WA. Effect of intra-articular hyaluronic injection on postural stability and risk of fall in patients with bilateral knee osteoarthritis. ScientificWorldJournal. 2014;2014:815184. doi: 10.1155/2014/815184. Epub 2014 Jun 19.

Reference Type DERIVED
PMID: 25136689 (View on PubMed)

Other Identifiers

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UM/MOHE/HIR D000010-16001

Identifier Type: -

Identifier Source: org_study_id

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