Safety and Immunogenicity of a Four Influenza Vaccines in Children Ages 6 Months Old to Less Than 48 Months Old

NCT ID: NCT02035696

Last Updated: 2018-07-10

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

671 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-12-31

Study Completion Date

2014-12-31

Brief Summary

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To evaluate the safety and immunogenicity of four influenza vaccines in children 6 months to \< 48 months of age

Detailed Description

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Conditions

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Influenza

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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TIVc-High Dose

Subjects (6 to \<48 months old) received two doses of 0.75 mL of TIVc vaccine

Group Type EXPERIMENTAL

Trivalent influenza vaccine (TIVc)

Intervention Type BIOLOGICAL

TIVc-Full Dose

Subjects(6 to \<48 months old) received two doses of 0.50 mL of TIVc vaccine

Group Type EXPERIMENTAL

Trivalent influenza vaccine (TIVc)

Intervention Type BIOLOGICAL

TIVc- Half Dose

Subjects (6 to \<48 months old)received two doses of 0.25 mL of TIVc vaccine

Group Type EXPERIMENTAL

Trivalent influenza vaccine (TIVc)

Intervention Type BIOLOGICAL

TIVe

Subjects (6 to \<48 months old) received two doses of TIVe vaccine(IM/0.25mL -for ages 6 to \<36 months and IM/ 0.5 mL -for ages 36 to \<48 months)

Group Type ACTIVE_COMPARATOR

Trivalent influenza vaccine-licensed

Intervention Type BIOLOGICAL

Licensed influenza vaccine

Interventions

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Trivalent influenza vaccine (TIVc)

Intervention Type BIOLOGICAL

Trivalent influenza vaccine-licensed

Licensed influenza vaccine

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Healthy subject, male or female, 6 through \< 48 months of age at the time of enrollment, who has never previously received an influenza vaccine
* Individual who has a parent or guardian that can give written informed consent after understanding the nature of the study and are available for follow-up

Exclusion Criteria

* Individuals recently vaccinated against influenza
* Subjects with contraindications to receive influenza vaccine
Minimum Eligible Age

6 Months

Maximum Eligible Age

48 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Novartis Vaccines

INDUSTRY

Sponsor Role collaborator

Seqirus

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Site 116

Phoenix, Arizona, United States

Site Status

Site 119

Tucson, Arizona, United States

Site Status

Site 109

Little Rock, Arkansas, United States

Site Status

Site 112

Long Beach, California, United States

Site Status

Site 113

Ontario, California, United States

Site Status

Site 117

San Diego, California, United States

Site Status

Site 114

West Covina, California, United States

Site Status

Site 107

Thornton, Colorado, United States

Site Status

Site 111

Miami, Florida, United States

Site Status

Site 108

Miami Beach, Florida, United States

Site Status

Site 121

Gainesville, Georgia, United States

Site Status

Site 101

Omaha, Nebraska, United States

Site Status

Site 104

Omaha, Nebraska, United States

Site Status

Site 105

Omaha, Nebraska, United States

Site Status

Site 106

Omaha, Nebraska, United States

Site Status

Site 103

Youngstown, Ohio, United States

Site Status

Site 102

Charleston, South Carolina, United States

Site Status

Site 115

Houston, Texas, United States

Site Status

Site 110

Salt Lake City, Utah, United States

Site Status

Site 118

St. George, Utah, United States

Site Status

Site 120

Spokane, Washington, United States

Site Status

Site 502

Kuopio, , Finland

Site Status

Site 506

Tampere, , Finland

Site Status

Site 302

City of Muntinlupa, , Philippines

Site Status

Site 301

Manila, , Philippines

Site Status

Site 201

Bangkok, , Thailand

Site Status

Site 202

Bangkok, , Thailand

Site Status

Countries

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United States Finland Philippines Thailand

Other Identifiers

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2013-002081-39

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

V58P16

Identifier Type: -

Identifier Source: org_study_id

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