Safety and Immunogenicity of Three Influenza Vaccines in Children Aged 4 Years Old to Less Than 18 Years Old

NCT ID: NCT01992107

Last Updated: 2015-12-08

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

2333 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-11-30

Study Completion Date

2014-08-31

Brief Summary

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Evaluate safety and immunogenicity of three influenza vaccines in children ages greater than 4 years old to less than 18 years old.

Detailed Description

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Conditions

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Influenza

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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QIVc (≥4 to <18 years)

Subjects received one or two doses of QIVc-Quadrivalent Cell-based Influenza Vaccine recommended for 2013-2014 season

Group Type EXPERIMENTAL

QIVc

Intervention Type BIOLOGICAL

Novartis Investigational Quadrivalent Vaccine

TIV1c (≥4 to <18 years)

Subjects received one or two doses of TIV1c (Trivalent Inactivated Cell-based Influenza Vaccine containing one strain from B lineage ("B1" strain) recommended for 2013-2014 season

Group Type ACTIVE_COMPARATOR

TIV1c

Intervention Type BIOLOGICAL

Licensed Influenza Vaccine

TIV2c (≥4 to <18 years)

Subjects received one or two doses of TIV2c (Trivalent Inactivated Cell-based Influenza Vaccine containing B strain from the alternate lineage ("B2" strain) recommended for 2013-2014

Group Type ACTIVE_COMPARATOR

TIV2c

Intervention Type BIOLOGICAL

Novartis Investigational Vaccine

Interventions

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QIVc

Novartis Investigational Quadrivalent Vaccine

Intervention Type BIOLOGICAL

TIV1c

Licensed Influenza Vaccine

Intervention Type BIOLOGICAL

TIV2c

Novartis Investigational Vaccine

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

1. Male or female aged 4 years to less than 18 years of age.
2. Individual who had a parent or guardian who could give written informed consent after understanding the nature of the study and comply with study procedures and were available for follow-up.
3. If the individual was of an age where, according to local regulations, informed assent is required, that individual had provided assent to participate in the study.

Exclusion Criteria

1. Individuals recently vaccinated against influenza
2. Subjects with contraindications to receive influenza vaccine
Minimum Eligible Age

4 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Novartis Vaccines

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Novartis Vaccines

Role: STUDY_CHAIR

Novartis Vaccines

Locations

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Huntsville, Alabama, United States

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Mobile, Alabama, United States

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Chandler, Arizona, United States

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Mesa, Arizona, United States

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Mesa, Arizona, United States

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Harrisburg, Arkansas, United States

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Jonesboro, Arkansas, United States

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Anaheim, California, United States

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Anaheim, California, United States

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Downey, California, United States

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Garden Grove, California, United States

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Modesto, California, United States

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Paramount, California, United States

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Sacramento, California, United States

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San Diego, California, United States

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San Francisco, California, United States

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Santa Rosa, California, United States

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West Covina, California, United States

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Colorado Springs, Colorado, United States

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Denver, Colorado, United States

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Denver, Colorado, United States

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Thornton, Colorado, United States

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Boca Raton, Florida, United States

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Lake Mary, Florida, United States

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Melbourne, Florida, United States

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Miami Beach, Florida, United States

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Opa-locka, Florida, United States

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Pinellas Park, Florida, United States

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Atlanta, Georgia, United States

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Marietta, Georgia, United States

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Woodstock, Georgia, United States

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Boise, Idaho, United States

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Peoria, Illinois, United States

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Mishawaka, Indiana, United States

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Council Bluffs, Iowa, United States

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Newton, Kansas, United States

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Wichita, Kansas, United States

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Wichita, Kansas, United States

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Lexington, Kentucky, United States

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Louisville, Kentucky, United States

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Metairie, Louisiana, United States

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Kansas City, Missouri, United States

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St Louis, Missouri, United States

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Bellevue, Nebraska, United States

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Fremont, Nebraska, United States

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Omaha, Nebraska, United States

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Omaha, Nebraska, United States

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Las Vegas, Nevada, United States

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Binghamton, New York, United States

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Wilmington, North Carolina, United States

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Akron, Ohio, United States

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Cincinnati, Ohio, United States

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Cleveland, Ohio, United States

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Cleveland, Ohio, United States

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Dayton, Ohio, United States

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Dayton, Ohio, United States

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Kettering, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Oklahoma City, Oklahoma, United States

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Tulsa, Oklahoma, United States

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Erie, Pennsylvania, United States

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Erie, Pennsylvania, United States

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Hermitage, Pennsylvania, United States

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Sellersville, Pennsylvania, United States

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Upper Saint Clair, Pennsylvania, United States

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Anderson, South Carolina, United States

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Charleston, South Carolina, United States

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Mt. Pleasant, South Carolina, United States

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Bristol, Tennessee, United States

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Jefferson City, Tennessee, United States

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Lebanon, Tennessee, United States

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Nashville, Tennessee, United States

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Austin, Texas, United States

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Dallas, Texas, United States

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Fort Worth, Texas, United States

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Fort Worth, Texas, United States

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Round Rock, Texas, United States

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San Angelo, Texas, United States

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San Antonio, Texas, United States

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Draper, Utah, United States

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Layton, Utah, United States

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Salt Lake City, Utah, United States

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Salt Lake City, Utah, United States

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Salt Lake City, Utah, United States

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South Jordan, Utah, United States

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West Jordan, Utah, United States

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Burke, Virginia, United States

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Charlottesville, Virginia, United States

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Countries

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United States

References

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Hartvickson R, Cruz M, Ervin J, Brandon D, Forleo-Neto E, Dagnew AF, Chandra R, Lindert K, Mateen AA. Non-inferiority of mammalian cell-derived quadrivalent subunit influenza virus vaccines compared to trivalent subunit influenza virus vaccines in healthy children: a phase III randomized, multicenter, double-blind clinical trial. Int J Infect Dis. 2015 Dec;41:65-72. doi: 10.1016/j.ijid.2015.11.004. Epub 2015 Nov 14.

Reference Type DERIVED
PMID: 26585940 (View on PubMed)

Other Identifiers

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V130_03

Identifier Type: -

Identifier Source: org_study_id