Clinical Study to Evaluate the Safety, Immunogenicity and Efficacy of Investigational Flu Vaccine Compared to Approved Flu Vaccine in Children.

NCT ID: NCT01964989

Last Updated: 2023-03-27

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

10644 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-11-30

Study Completion Date

2016-08-31

Brief Summary

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Safety, Immunogenicity and Efficacy of an Adjuvanted Quadrivalent Subunit Influenza Virus Vaccine Compared to Non-Adjuvanted Comparator Influenza Vaccine in Children ≥6 to \<72 Months of Age. The study was conducted during the 2013/2014 and 2014/2015 northern hemisphere influenza season.

Detailed Description

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Conditions

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Influenza Virus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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aQIV

flu vaccine

Group Type EXPERIMENTAL

Adjuvanted Quadrivalent Subunit Influenza Virus Vaccine (aQIV)

Intervention Type BIOLOGICAL

1 or 2 doses (naïve / non-naive subjects) 0.25 ml: ≥6 months to \<36 months, 0.5 ml: ≥36 months to \<72 months

non-adjuvanted comparator

flu vaccine

Group Type ACTIVE_COMPARATOR

Non-adjuvanted Trivalent Influenza Vaccine (TIV) / Quadrivalent Influenza Vaccine (QIV)

Intervention Type BIOLOGICAL

1 or 2 doses (naïve / non-naive subjects) 0.25 ml: ≥6 months to \<36 months, 0.5 ml: ≥36 months to \<72 months

Interventions

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Adjuvanted Quadrivalent Subunit Influenza Virus Vaccine (aQIV)

1 or 2 doses (naïve / non-naive subjects) 0.25 ml: ≥6 months to \<36 months, 0.5 ml: ≥36 months to \<72 months

Intervention Type BIOLOGICAL

Non-adjuvanted Trivalent Influenza Vaccine (TIV) / Quadrivalent Influenza Vaccine (QIV)

1 or 2 doses (naïve / non-naive subjects) 0.25 ml: ≥6 months to \<36 months, 0.5 ml: ≥36 months to \<72 months

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Children, males and females, healthy or at high risk of complications from influenza, between ≥6 months to \<72 months of age
* Documented consent provided by the subject's parent(s)/legal guardian(s)
* Subjects and/or subject's parent(s)/legal guardian(s) able to comply with all study procedures.

Exclusion Criteria

* Children with history of allergy to vaccine components.
* Additional eligibility criteria may be discussed by contacting the site
Minimum Eligible Age

6 Months

Maximum Eligible Age

71 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Novartis Vaccines

INDUSTRY

Sponsor Role collaborator

Seqirus

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Program Director

Role: STUDY_DIRECTOR

Seqirus

Locations

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222, Novartis Investigational Site

Chandler, Arizona, United States

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267, Novartis Investigational Site

Harrisburg, Arkansas, United States

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259, Novartis Investigational Site

Anaheim, California, United States

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280, Novartis Investigational Site

Anaheim, California, United States

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213, Novartis Investigational Site

Baldwin Park, California, United States

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407, Novartis Investigational Site

Downey, California, United States

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238, Novartis Investigational Site

La Puente, California, United States

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411, Novartis Investigational Site

Ontario, California, United States

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202, Novartis Investigational Site

Paramount, California, United States

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250, Novartis Investigational Site

San Diego, California, United States

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293, Novartis Investigational Site

San Francisco, California, United States

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243, Novartis Investigational Site

Colorado Springs, Colorado, United States

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249, Novartis Investigational Site

Denver, Colorado, United States

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229, Novartis Investigational Site

Boca Raton, Florida, United States

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416, Novartis Investigational Site

Hialeah, Florida, United States

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287, Novartis Investigational Site

Hialeah, Florida, United States

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412, Novartis Investigational Site

Homestead, Florida, United States

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224, Novartis Investigational Site

Melbourne, Florida, United States

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417, Novartis Investigational Site

Miami, Florida, United States

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404, Novartis Investigational Site

Miami, Florida, United States

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285, Novartis Investigational Site

Miami, Florida, United States

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277,Novartis Investigational Site

Miami, Florida, United States

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234, Novartis Investigational Site

Opa-locka, Florida, United States

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297, Novartis Investigational Site

Orlando, Florida, United States

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297, Novartis Investigational vaccine

Orlando, Florida, United States

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410, Novartis Investigational Site

Sarasota, Florida, United States

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401, Novartis iNvestiagtional Site

Atlanta, Georgia, United States

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299, Novartis Investigational Site

DeKalb, Illinois, United States

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268, Novartis Investigational Site

Peoria, Illinois, United States

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209, Novartis Investigational Site

Augusta, Kansas, United States

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210, Novartis Investigational Site

Newton, Kansas, United States

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274 Novartis Investigational Site

Park City, Kansas, United States

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211, Novartis Investigational Site

Wichita, Kansas, United States

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269, Novartis Investigational Site

Bardstown, Kentucky, United States

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226, Novartis Investigational Site

Louisville, Kentucky, United States

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248, Novartis Investigational Site

Louisville, Kentucky, United States

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207, Novartis Investigational Site

Louisville, Kentucky, United States

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290, Novartis Investigational Site

Louisville, Kentucky, United States

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265, Novartis Investigational Site

Haughton, Louisiana, United States

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408, Novartis Investigational Site

Mangham, Louisiana, United States

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225, Novartis Investigational Site

Metairie, Louisiana, United States

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233, Novartis Investigational Site

Metairie, Louisiana, United States

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418, Novartis Investigational SIte

Monroe, Louisiana, United States

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262, Novartis Investigational site

Annapolis, Maryland, United States

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263, Novartis Investigational Site

Frederick, Maryland, United States

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405, Novartis Investigational Site

Silver Spring, Maryland, United States

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278, Novartis Investigational Site

Saint Paul, Minnesota, United States

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221, Novartis Investigational Site

Bellevue, Nebraska, United States

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219, Novartis Investigational Site

Fremont, Nebraska, United States

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402, Novartis Investigational Site

Omaha, Nebraska, United States

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288, Novartis Investigational Site

Omaha, Nebraska, United States

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228, Novartis Investigational Site

Omaha, Nebraska, United States

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244, Novartis Investigational Site

Henderson, Nevada, United States

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286, Novartis Investigational site

Las Vegas, Nevada, United States

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255, Novartis Investigational Site

Binghamton, New York, United States

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Brooklyn, New York, United States

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264, Novartis Investigational Site

Syracuse, New York, United States

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409, Novartis Investigational Site

Boone, North Carolina, United States

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266, Novartis Investigational Site

Cary, North Carolina, United States

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403, Novartis Investigational Site

Clyde, North Carolina, United States

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240, Novartis Investigational Site

Akron, Ohio, United States

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Cleveland, Ohio, United States

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245, Novartis Investigational Site

Dayton, Ohio, United States

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281, Novartis Investigational Site

Dayton, Ohio, United States

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Dayton, Ohio, United States

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256, Novartis Investigational Site

Tulsa, Oklahoma, United States

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Erie, Pennsylvania, United States

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Scottdale, Pennsylvania, United States

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Anderson, South Carolina, United States

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Barnwell, South Carolina, United States

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Charleston, South Carolina, United States

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232, Novartis Investigational Site

Moncks Corner, South Carolina, United States

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Spartanburg, South Carolina, United States

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283, Novartis Investigational Site

Nashville, Tennessee, United States

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208, Novartis Investigational Site

Austin, Texas, United States

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247, Novartis Investigational Site

Fort Worth, Texas, United States

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217, Novartis Investigational Site

Fort Worth, Texas, United States

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San Angelo, Texas, United States

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San Antonio, Texas, United States

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260, Novartis Investigational Site

Tomball, Texas, United States

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Layton, Utah, United States

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Salt Lake City, Utah, United States

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212, Novartis Investigational Site

Salt Lake City, Utah, United States

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246, Novartis Investigational Site

Salt Lake City, Utah, United States

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279, Novartis Investigational Site

Spanish Fork, Utah, United States

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Syracuse, Utah, United States

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294, Novartis Investigational Site

West Haven, Utah, United States

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201, Novartis Investigational Site

West Jordan, Utah, United States

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271, Novartis Investigational Site

West Jordan, Utah, United States

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251, Novartis Investigational Site

Burke, Virginia, United States

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296, Novartis Investigational Site

Vienna, Virginia, United States

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184, Novartis Investigational Site

Greater Sudbury, Ontario, Canada

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Newmarket, Ontario, Canada

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Toronto, Ontario, Canada

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Québec, , Canada

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Québec, , Canada

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Espoo, , Finland

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Helsinki, , Finland

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Helsinki, , Finland

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Järvenpää, , Finland

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Kokkola, , Finland

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Oulu, , Finland

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Pori, , Finland

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Seinäjoki, , Finland

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Tampere, , Finland

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Turku, , Finland

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Vantaa, , Finland

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Florence, , Italy

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Genova, , Italy

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Milan, , Italy

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Milan, , Italy

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Napoli, , Italy

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Novara, , Italy

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Padua, , Italy

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Pisa, , Italy

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Sassari, , Italy

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173, Novartis Investigational Site

Morelia, Michoacán, Mexico

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Durango, , Mexico

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170, Novartis Investigational Site

México, , Mexico

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México, , Mexico

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México, , Mexico

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175, Novartis Investigational Site

México, , Mexico

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300, Novartis Investigational Site

Dasmariñas, Cavite, Philippines

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306, Novartis Investigational Site

Alabang, Muntilupa, Philippines

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303, Novartis Investigational Site

City of Muntinlupa, , Philippines

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304, Novartis Investigational Site

City of Muntinlupa, , Philippines

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City of Muntinlupa, , Philippines

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Manila, , Philippines

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301, Novartis Investigational Site

Manila, , Philippines

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040, Novartis Investigational Site

Dębica, , Poland

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Katowice, , Poland

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048, Novartis Investigational Site

Lodz, , Poland

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049, Novartis Investigational Site

Lubartów, , Poland

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051, Novartis Investigational Site

Oborniki Śląskie, , Poland

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Osielsko, , Poland

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Siemianowice Śląskie, , Poland

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047, Novartis Investigational Site

Tarnów, , Poland

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Warsaw, , Poland

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050, Novartis Investigational Site

Warsaw, , Poland

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Wola, , Poland

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Wroclaw, , Poland

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052, Novartis Investigational Site

Łęczna, , Poland

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257, Novartis Investigational Site

Ponce, , Puerto Rico

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415, Novartis Investigational vaccine

San Juan, , Puerto Rico

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415, Novartis Investigational Site

San Juan, , Puerto Rico

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80, Novartis Investigational Site

Sabadell, Barcelona, Spain

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075, Novartis Investigational Site

Santiago de Compostela, Galicia, Spain

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074, Novartis Investigational Site

Granada, , Spain

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076, Novartis Investigational Site

Madrid, , Spain

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Madrid, , Spain

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79, Novartis Investigational Site

Málaga, , Spain

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078, Novartis Investigational Site

Valencia, , Spain

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343, Novartis Investigational Site

Banqiao District, New Taipei City, Taiwan

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346, Novartis Investigational Site

Datong, Taipei City, Taiwan

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344, Novartis Investigational Site

Taichung, , Taiwan

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345, Novartis Investigational Site

Taichung, , Taiwan

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340, Novartis Investigational Site

Taipei, , Taiwan

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341, Novartis Investigational Site

Taipei, , Taiwan

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342, Novartis Investigational Site

Taoyuan District, , Taiwan

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321, Novartis Investigational Site

Bangkoknoi, Bangkok, Thailand

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322, Novartis Investigational Site

Bangkoknoi, Bangkok, Thailand

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323, Novartis Investigational Site

Pathum Wan, Bangkok, Thailand

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327, Novartis Investigational Site

Ratchathewi, Bangkok, Thailand

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325, Novartis Investigational Site

Pathum Thani, Changwat Pathum Thani, Thailand

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326, Novartis Investigational Site

Hat Yai, Songkhia, Thailand

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320, Novartis Investigational Site

Bangkok, , Thailand

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324, Novartis Investigational Site

Bangkok, , Thailand

Site Status

Countries

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United States Canada Finland Italy Mexico Philippines Poland Puerto Rico Spain Taiwan Thailand

References

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Esposito S, Fling J, Chokephaibulkit K, de Bruijn M, Oberye J, Zhang B, Vossen J, Heijnen E, Smolenov I. Immunogenicity and Safety of an MF59-adjuvanted Quadrivalent Seasonal Influenza Vaccine in Young Children at High Risk of Influenza-associated Complications: A Phase III, Randomized, Observer-blind, Multicenter Clinical Trial. Pediatr Infect Dis J. 2020 Aug;39(8):e185-e191. doi: 10.1097/INF.0000000000002727.

Reference Type DERIVED
PMID: 32404782 (View on PubMed)

Vesikari T, Kirstein J, Devota Go G, Leav B, Ruzycky ME, Isakov L, de Bruijn M, Oberye J, Heijnen E. Efficacy, immunogenicity, and safety evaluation of an MF59-adjuvanted quadrivalent influenza virus vaccine compared with non-adjuvanted influenza vaccine in children: a multicentre, randomised controlled, observer-blinded, phase 3 trial. Lancet Respir Med. 2018 May;6(5):345-356. doi: 10.1016/S2213-2600(18)30108-5. Epub 2018 Apr 6.

Reference Type DERIVED
PMID: 29631857 (View on PubMed)

Other Identifiers

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2012-000218-12

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

V118_05

Identifier Type: -

Identifier Source: org_study_id

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