Safety of Two Trivalent Influenza Vaccines Evaluated in Children and Adolescents 4 to 17 Years of Age

NCT ID: NCT01857206

Last Updated: 2014-12-05

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

2055 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-05-31

Study Completion Date

2014-06-30

Brief Summary

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Evaluate safety and tolerability of TIVa or TIVb vaccine in healthy children and adolescents 4 to 17 years of age.

Detailed Description

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Conditions

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Influenza Fever

Keywords

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Influenza children and adolescents trivalent vaccine cell culture embryonated chicken eggs

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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TIVc

Subjects ≥4 to ≤17 years of age received one or two doses of mammalian cell-culture-derived trivalent influenza vaccine based on their previous vaccination status.

Group Type EXPERIMENTAL

Mammalian cell based flu vaccine

Intervention Type BIOLOGICAL

TIVf

Subjects ≥4 to ≤17 years of age received one or two doses of egg-derived trivalent influenza vaccine based on their previous vaccination status.

Group Type ACTIVE_COMPARATOR

Egg based flu vaccine

Intervention Type BIOLOGICAL

Interventions

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Mammalian cell based flu vaccine

Intervention Type BIOLOGICAL

Egg based flu vaccine

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

\- Healthy subjects 4-17 years of age

Exclusion Criteria

* Subjects who are not healthy,
* Subjects who are pregnant or breast feeding,
* Subjects with a history of severe allergic reaction or allergic to any of the vaccine components.
Minimum Eligible Age

4 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Novartis Vaccines

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Novartis Vaccines and Diagnostics

Role: STUDY_CHAIR

Novartis Vaccines

Locations

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320, Novartis Investigational Site

Mobile, Alabama, United States

Site Status

312, Novartis Investigational Site

Ponte Vedra, Florida, United States

Site Status

313, Novartis Investigational Site

Augusta, Kansas, United States

Site Status

305, Novartis Investigational Site

Newton, Kansas, United States

Site Status

302, Novartis Investigational Site

Wichita, Kansas, United States

Site Status

301, Novartis Investigational Site

Wichita, Kansas, United States

Site Status

311, Novartis Investigational Site

Fremont, Nebraska, United States

Site Status

308, Novartis Investigational Site

Winston-Salem, North Carolina, United States

Site Status

317, Novartis Investigational Site

Cleveland, Ohio, United States

Site Status

309, Novartis Investigational Site

Tulsa, Oklahoma, United States

Site Status

314, Novartis Investigational Site

Warwick, Rhode Island, United States

Site Status

319, Novartis Investigational Site

Mt. Pleasant, South Carolina, United States

Site Status

310, Novartis Investigational Site

Bristol, Tennessee, United States

Site Status

318, Novartis Investigational Site

Nashville, Tennessee, United States

Site Status

304, Novartis Investigational Site

Salt Lake City, Utah, United States

Site Status

306, Novartis Investigational Site

Salt Lake City, Utah, United States

Site Status

315, Novartis Investigational Site

Salt Lake City, Utah, United States

Site Status

303, Novartis Investigational Site

South Jordan, Utah, United States

Site Status

100, Novartis Investigational Site

Westmead, New South Wales, Australia

Site Status

108, Novartis Investigational Site

Auchenflower, Queensland, Australia

Site Status

107, Novartis Investigational Site

Sherwood, Queensland, Australia

Site Status

104, Novartis Investigational Site

North Adelaide, South Australia, Australia

Site Status

103, Novartis Investigational Site

Carlton, Victoria, Australia

Site Status

105, Novartis Investigational Site

Subiaco, Western Australia, Australia

Site Status

151, Novartis Investigational Site

Takapuna, Auckland, New Zealand

Site Status

150, Novartis Investigational Site

Beckenham, Christchurch, New Zealand

Site Status

250, Novartis Investigational Site

City of Muntinlupa, Alabang, Philippines

Site Status

251, Novartis Investigational Site

City of Muntinlupa, Alabang, Philippines

Site Status

254, Novartis Investigational Site

City of Muntinlupa, Alabang, Philippines

Site Status

253, Novartis Investigational Site

Manila, Ermita, Philippines

Site Status

252, Novartis Investigation Site

Manila, Sampaloc, Philippines

Site Status

201, Novartis Investigational Site

Khon Kaen, Muang, Thailand

Site Status

200, Novartis Investigational Site

Bangkok, Rajathevi, Thailand

Site Status

202, Novartis Investigational Site

Bangkoknoi, Siriraj, Thailand

Site Status

Countries

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United States Australia New Zealand Philippines Thailand

References

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Nolan T, Chotpitayasunondh T, Capeding MR, Carson S, Senders SD, Jaehnig P, de Rooij R, Chandra R. Safety and tolerability of a cell culture derived trivalent subunit inactivated influenza vaccine administered to healthy children and adolescents: A Phase III, randomized, multicenter, observer-blind study. Vaccine. 2016 Jan 4;34(2):230-236. doi: 10.1016/j.vaccine.2015.11.040. Epub 2015 Nov 29.

Reference Type DERIVED
PMID: 26643931 (View on PubMed)

Other Identifiers

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U1111-1139-9440

Identifier Type: OTHER

Identifier Source: secondary_id

V58_31

Identifier Type: -

Identifier Source: org_study_id