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Genetic Polymorphisms & The Risk for Sepsis After Trauma

NCT ID: NCT02021552

Last Updated: 2016-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

357 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-06-30

Study Completion Date

2015-12-31

Brief Summary

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The specific aim of this is to establish a cohort of severely injured patients admitted to our trauma center. Investigators will collect DNA, utilizing discarded blood samples, from 3000 injury victims in an effort to identify perhaps 50 - 100 single-nucleotide polymorphisms (SNP) (out of 1000s) that can be used, when taken together, to identify patients at highest risk for developing complicated sepsis and death.

Detailed Description

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The specific aim of this is to establish a cohort of severely injured patients admitted to our trauma center. Investigators will collect DNA, utilizing discarded blood samples, from 3000 injury victims in an effort to identify perhaps 50 - 100 single-nucleotide polymorphisms (SNP) (out of 1000s) that can be used, when taken together, to identify patients at highest risk for developing complicated sepsis and death

Conditions

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Trauma

Keywords

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Trauma Sepsis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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trauma patients

trauma patients 18 years or older requiring treatment in the ICU \>24 hours. All subjects will undergo blood sampling.

blood sampling

Intervention Type OTHER

5 ml blood sampling

Interventions

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blood sampling

5 ml blood sampling

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Admitted to the Intensive Care Unit (ICU) at Harborview Medical Center after suffering a traumatic injury

* ability to obtain a 5 ml blood sample
* Expected to be in the ICU for more than 24 hours

Exclusion Criteria

* We will exclude subjects with chronic medical conditions for the reasons stated above as well as vulnerable populations (children, pregnant females, and prisoners)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Washington

OTHER

Sponsor Role lead

Responsible Party

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Grant E. O'Keefe

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Grant O'Keefe, MD

Role: PRINCIPAL_INVESTIGATOR

Professor; Dept of Surgery

Locations

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Harborview Medical Center

Seattle, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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44109-A

Identifier Type: -

Identifier Source: org_study_id