The Effect of Vitrification Versus Slow Freezing on Day 3: a Randomised Controlled Trial.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

417 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-09-30

Study Completion Date

2014-05-31

Brief Summary

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Randomized controlled trial (RCT) testing the hypothesis that vitrification is superior to slow freezing.

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Detailed Description

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Conditions

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Cryopreservation of Embryos

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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cryopreservation technique

slow freezing cryopreservation technique

Group Type ACTIVE_COMPARATOR

cryopreservation technique

Intervention Type OTHER

vitrification cryopreservation technique

Group Type ACTIVE_COMPARATOR

cryopreservation technique

Intervention Type OTHER

Interventions

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cryopreservation technique

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients (with female age \< 40 years)
* Patients undergoing a 1st oocyte retrieval for an IVF/Intracytoplasmatic Sperm Injection (ICSI) treatment
* Patients planned for an embryo transfer on day 3.
* Patients with supernumerary embryos of sufficient quality for freezing/vitrifying on day 3.
* Fresh personal (own oocytes)
* One inclusion in the study per patient.

Exclusion Criteria

* Patients undergoing a 2nd or higher ranked oocyte retrieval after a fresh cycle with failed pregnancy.
* Female age ≥ 40 year
* Patients with Preimplantation Genetic Diagnosis (PGD)
* Patients with donor oocytes
* Patients with positive serology whose embryos may not be frozen.
* Patients planned for a transfer on day 2 or day 5.
* Patients receiving assisted hatching in the embryo transfer in the frozen cycles.
* Patients who have been included in the study before.

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No