Vitrification Versus Spontaneous Conception and Slow- Rate Freezing
NCT ID: NCT01088425
Last Updated: 2017-03-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
850 participants
OBSERVATIONAL
2010-03-31
2015-12-31
Brief Summary
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In the last years a shift from the well established method of slow-rate freezing to vitrification of 2PN zygotes and embryos could be observed. Like any other method of cryopreservation, the outcome of vitrification will be affected by several factors related to technique itself, its practical management and patient characteristics.
The investigators want to investigate the influence of vitrification on the outcome of of 2PN oocytes, pregnancy and infant health.
A Comparison between a cohort of spontaneous conceived children and children of vitrified and slow- cooled 2PN oocytes is planned.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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Spontaneous
Mothers with children conceived after spontaneous cycle
Observation
Alberta infant motor scale
Griffiths test
Kauffmann ABC
Vitrificatíon
Mothers with children conceived after vitrification cycle
Observation
Alberta infant motor scale
Griffiths test
Kauffmann ABC
slow- rate freezing
Mothers with children conceived after slow- rate freezing cycle
Observation
Alberta infant motor scale
Griffiths test
Kauffmann ABC
Interventions
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Observation
Alberta infant motor scale
Griffiths test
Kauffmann ABC
Eligibility Criteria
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Inclusion Criteria
* Treatment in Lübeck University
* Delivery in Lübeck University
* Positive informed consent
Exclusion Criteria
ALL
No
Sponsors
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University of Luebeck
OTHER
Responsible Party
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Daniel Alexander Beyer
Dr. D. A. Beyer
Principal Investigators
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Daniel A Beyer, MD
Role: PRINCIPAL_INVESTIGATOR
Lübeck University
Locations
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Schleswig- Holstein University, Campus Lübeck, Department of Reproductive Medicine
Lübeck, Schleswig-Holstein, Germany
Countries
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References
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Wennerholm UB, Soderstrom-Anttila V, Bergh C, Aittomaki K, Hazekamp J, Nygren KG, Selbing A, Loft A. Children born after cryopreservation of embryos or oocytes: a systematic review of outcome data. Hum Reprod. 2009 Sep;24(9):2158-72. doi: 10.1093/humrep/dep125. Epub 2009 May 20.
Kagawa N, Kuwayama M, Nakata K, Vajta G, Silber S, Manabe N, Kato O. Production of the first offspring from oocytes derived from fresh and cryopreserved pre-antral follicles of adult mice. Reprod Biomed Online. 2007 Jun;14(6):693-9. doi: 10.1016/s1472-6483(10)60670-0.
Noyes N, Porcu E, Borini A. Over 900 oocyte cryopreservation babies born with no apparent increase in congenital anomalies. Reprod Biomed Online. 2009 Jun;18(6):769-76. doi: 10.1016/s1472-6483(10)60025-9.
Noyes N, Knopman J, Labella P, McCaffrey C, Clark-Williams M, Grifo J. Oocyte cryopreservation outcomes including pre-cryopreservation and post-thaw meiotic spindle evaluation following slow cooling and vitrification of human oocytes. Fertil Steril. 2010 Nov;94(6):2078-82. doi: 10.1016/j.fertnstert.2010.01.019. Epub 2010 Feb 26.
Ubaldi F, Anniballo R, Romano S, Baroni E, Albricci L, Colamaria S, Capalbo A, Sapienza F, Vajta G, Rienzi L. Cumulative ongoing pregnancy rate achieved with oocyte vitrification and cleavage stage transfer without embryo selection in a standard infertility program. Hum Reprod. 2010 May;25(5):1199-205. doi: 10.1093/humrep/deq046. Epub 2010 Feb 25.
Al-Hasani S, Ozmen B, Koutlaki N, Schoepper B, Diedrich K, Schultze-Mosgau A. Three years of routine vitrification of human zygotes: is it still fair to advocate slow-rate freezing? Reprod Biomed Online. 2007 Mar;14(3):288-93. doi: 10.1016/s1472-6483(10)60869-3.
Other Identifiers
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09-195
Identifier Type: REGISTRY
Identifier Source: secondary_id
UKSH-HL-09-195
Identifier Type: -
Identifier Source: org_study_id
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