Intrathecal Morphine for Inguinal Hernia Repair.

NCT ID: NCT02001948

Last Updated: 2013-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

46 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-07-31

Study Completion Date

2010-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this study was to compare the effects of two different doses of intrathecal morphine (0.1 mg and 0.4 mg) combined with 7.5 mg of heavy bupivacaine on postoperative block regression times, postoperative analgesia and the severity of side effects, for inguinal hernia repairs.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The purpose of this study was to compare spinal anesthesia with low dose heavy bupivacaine combined with 0.1 mg or 0.4 mg of morphine in inguinal hernia repair surgeries. Anesthesia onset time (sensory and motor blocks) as well as postoperative recovery (first mobilisation, first voiding) time were compared. Also the postoperative pain management and side effects (nausea, vomiting and pruritus) were assessed.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Inguinal Hernia Nausea Vomiting Pruritus Postoperative Pain

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Spinal anaesthesia morphine postoperative analgesia vomiting

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

intrathecal morphine 0.1 mg

After routine monitorisation, intravenous cannulation and premedication, patients in this group will receive a spinal anaesthesia with 0.1 mg morphine combined with 7.5 mg heavy bupivacaine

Group Type ACTIVE_COMPARATOR

intrathecal morphine 0.1 mg combined with intrathecal heavy bupivacaine 7.5 mg

Intervention Type DRUG

standard monitoring with Datex Ohmeda anesthesia monitor, GE, Finland

Intervention Type DEVICE

electrocardiography, heart rate, pulse oximetry and noninvasive arterial blood pressure

intravenous cannulation and premedication

Intervention Type DRUG

18-gauge intravenous cannula was inserted at the forearm opposite to the surgical side and routine iv premedication (midazolam 0.03 mg/kg) was given

0.4 mg of intrathecal morphine

After routine monitorisation, intravenous cannulation and premedication, patients in this group will receive spinal anesthesia with 0.4 mg of morphine combined with 7.5 mg of heavy bupivacaine.

Group Type ACTIVE_COMPARATOR

intrathecal morphine 0.4 mg combined with intrathecal heavy bupivacaine 7.5 mg

Intervention Type DRUG

standard monitoring with Datex Ohmeda anesthesia monitor, GE, Finland

Intervention Type DEVICE

electrocardiography, heart rate, pulse oximetry and noninvasive arterial blood pressure

intravenous cannulation and premedication

Intervention Type DRUG

18-gauge intravenous cannula was inserted at the forearm opposite to the surgical side and routine iv premedication (midazolam 0.03 mg/kg) was given

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

intrathecal morphine 0.1 mg combined with intrathecal heavy bupivacaine 7.5 mg

Intervention Type DRUG

intrathecal morphine 0.4 mg combined with intrathecal heavy bupivacaine 7.5 mg

Intervention Type DRUG

standard monitoring with Datex Ohmeda anesthesia monitor, GE, Finland

electrocardiography, heart rate, pulse oximetry and noninvasive arterial blood pressure

Intervention Type DEVICE

intravenous cannulation and premedication

18-gauge intravenous cannula was inserted at the forearm opposite to the surgical side and routine iv premedication (midazolam 0.03 mg/kg) was given

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* American Society of Anaesthesiology physical status I-II patients
* aged 18-65 years
* undergoing elective unilateral open inguinal hernia repair surgery

Exclusion Criteria

* contraindications to spinal anesthesia
* central or peripheral neuropathies
* severe respiratory or cardiac diseases
* chronic analgesic use
* history of substance abuse
* allergy to local anesthetics
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Ankara University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Basak Ceyda MECO

MD, DESA

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Basak Ceyda Meco

Role: PRINCIPAL_INVESTIGATOR

Ankara University Faculty of Medicine

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Ankara University Faculty of Medicine, Ibni Sina Hospital general surgery OR

Ankara, , Turkey (Türkiye)

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Turkey (Türkiye)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

11-02-09

Identifier Type: -

Identifier Source: org_study_id