Determination of Adipocytokine in Synovial Fluid of Osteoarthritis Patients

NCT ID: NCT01993342

Last Updated: 2013-11-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

35 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-10-31

Study Completion Date

2014-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to determine the concentration of different adipocytokine (adiponectin, leptin, resistin, visfatin, osteopontin) and an inflammation classic markers as Interleukine 1 beta, tumor necrosis alfa, interleukine 6 and high sensibility reactive c protein in the synovial fluid of knee osteoarthritis patients, and compare with the inflammation detected with ultrasonography evaluation of the joint. In last years, some studies appeared focusing on the role of adipocytokines in osteoarthritis and they correlated adipocytokines with cartilage degradation and x-ray degree; in our study we will focused in the importance of adipocytokines in the inflammatory changes more than in joint destruction.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Osteoarthritis

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

adipocytokines osteoarthritis inflammation ultrasonography

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Inflammatory knee osteoarthritis

We recruited patients with osteoarthritis and synovial effusion to diagnostic the effusion and to confirm that this this synovial fluid had mechanical characteristics. Now we are going to determine the adipocytokines and traditional parameters of inflammation in this synovial fluid to correlate it, and we will associate it with the ultrasound explanation of the knee that we have in our database.

arthrocentesis

Intervention Type OTHER

The made a diagnostic arthrocentesis to all patient we included

ultrasonography of the knee

Intervention Type OTHER

We explored the affected knee with an ultrasound explanation in order to describe inflammatory changes based on standard examination.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

arthrocentesis

The made a diagnostic arthrocentesis to all patient we included

Intervention Type OTHER

ultrasonography of the knee

We explored the affected knee with an ultrasound explanation in order to describe inflammatory changes based on standard examination.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* aged 50 to 81
* primary osteoarthritis of the knee
* synovial effusion in examination
* patient who have the results in our database

Exclusion Criteria

* any other rheumatic conditions as rheumatoid arthritis or another inflammatory disease
* secondary knee osteoarthritis
* history of knee surgery
* any conditions that at investigator criteria exclude the patient from study procedures
Minimum Eligible Age

50 Years

Maximum Eligible Age

81 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Parc TaulĂ­ Hospital Universitari

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Joan Calvet Fontova

Dr

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Joan Calvet, Dr

Role: PRINCIPAL_INVESTIGATOR

Hospital Parc Tauli

Cristobal Orellana, Dr

Role: STUDY_DIRECTOR

Hospital Parc Tauli

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Hospital Parc Tauli Sabadell

Sabadell, Barcelona, Spain

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Spain

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Joan Calvet, Dr

Role: CONTACT

Phone: 0034 937231010

Email: [email protected]

Cristobal Orellana, Dr

Role: CONTACT

Phone: 0034 937231010

Email: [email protected]

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Joan Calvet, Dr

Role: primary

Cristobal Orellana, Dr

Role: backup

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

Joan03

Identifier Type: -

Identifier Source: org_study_id