Using Ultrasound to Predict Response to Intraarticular Corticosteroids in Knee Osteoarthritis

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

79 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-03-31

Study Completion Date

2008-09-30

Brief Summary

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A study using characteristics on ultrasound to predict response to intraarticular steroid injections in patients with knee osteoarthritis. The hypothesis is that patients with inflammation on ultrasound will have a better response to corticosteroid injections compared to patients without inflammation.

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Detailed Description

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Conditions

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Osteoarthritis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Study Groups

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Corticosteroid Injection

40 mg of intraarticular triamcinolone acetonide

Group Type ACTIVE_COMPARATOR

triamcinolone acetonide

Intervention Type DRUG

single intraarticular injection of 40 mg of triamcinolone acetonide

Placebo Injection

Intraarticular injection of 0.9% saline

Group Type PLACEBO_COMPARATOR

saline

Intervention Type DRUG

Single intraarticular injection of 1 ml of 0.9% saline

Interventions

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triamcinolone acetonide

single intraarticular injection of 40 mg of triamcinolone acetonide

Intervention Type DRUG

saline

Single intraarticular injection of 1 ml of 0.9% saline

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* knee pain
* diagnosis of osteoarthritis in affected knee

Exclusion Criteria

* intraarticular corticosteroids in affected knee within past three months
* primary inflammatory connective tissue disease (ie rheumatoid arthritis)
* currently taking oral corticosteroids

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No