Hiperemezis and Serotonin Elevated Serum Serotonin Levels in Hyperemesis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-10-31

Study Completion Date

2014-03-31

Brief Summary

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Serotonin excretion was investigated in the nausea and vomiting associated with hiperemezis gravid arum.

Detailed Description

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The occurrence of severe nausea and vomiting of early pregnancy (hiperemezis gravid arum) is estimated between 0.3% to 1% of all pregnancies. Although hiperemezis gravid arum has been recognized for a long time, its pathophysiologic mechanisms are still poorly understood. Many theories have been advocated, but to date none of these have been convincing.

It has been demonstrated that the nausea and vomiting associated with increased in serotonin liberation. This has provided a rationale for the treatment of these symptoms with specific serotonin antagonists.

The aim of this trial was to investigate the possible relationship between hiperemezis gravid arum and serotonin liberation.

Conditions

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Nausea Vomiting Markedly Reduced Food Intake Severe Dehydration

Keywords

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hiperemesis gravidarum,vomiting,serotonin levels,ketonuria

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* 6-14 week pregnant women
* nausea
* protracted vomiting
* inability to tolerate food intake accompanied by obvious dehydration
* severe enough to justify hospitalisation
* at least 2+ ketonuria on dipstick urinanalysis.

Exclusion Criteria

* with metabolic disorders such as diabet, thyroid

Minimum Eligible Age

15 Years

Maximum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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hüseyin cengiz, md

Role: STUDY_CHAIR

Bakırkoy Dr. Sadi Konuk Training and Research Hospital

Locations

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Bakirkoy Dr Sadi Konuk Training and Research Hospital

Istanbul, Istanbul, Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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hediye dağdeviren, md

Role: CONTACT

Phone: 5079872463

Email: [email protected]

Facility Contacts

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hediye dagdeviren, md

Role: primary

Other Identifiers

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2013-88

Identifier Type: -

Identifier Source: org_study_id