Memory Training Versus Yogic Meditation Training in Older Adults With Mild Cognitive Impairment

NCT ID: NCT01983930

Last Updated: 2018-10-23

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 81 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-09-30
• Study Completion Date: 2016-05-31

Brief Summary

The purpose of this pilot study is to test whether 6 months of supervised weekly Kundalini yoga classes and a brief daily meditation homework assignment can improve memory and thinking in older adults with mild memory complaints when compared to weekly classes of memory training with daily homework assignments.

Detailed Description

The purpose of this pilot study intervention is to investigate brain mechanisms of response to memory enhancement training (MET) compared to Kundalini yoga and "Kirtan Kriya" meditation using functional magnetic resonance imaging (fMRI) that will be acquired from each subject at baseline and at 12 weeks (post-randomization).

Overall, the investigators anticipate recruiting 66 adults with memory complaints and diagnosed with MCI for adults 55 years old and older. Subjects will either receive: (1) MET class for 60 minutes per week; or (2) Kundalini yoga and "Kirtan Kriya" meditation class for 60 minutes per week. All assessments will be completed immediately after the interventions for a total of 10 visits in 12 weeks and a follow-up visit at 6 months (24 weeks)to monitor the overall benefit of the intervention.

Conditions

Mild Cognitive Impairment

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: NONE

Study Groups

Memory Training

Group memory training will be administered for amnestic mild cognitive impairment (MCI)

Group Type: ACTIVE_COMPARATOR

Memory Training

Intervention Type: BEHAVIORAL

Participants will attend a weekly memory training class for 12 weeks as well as receive daily memory homework (12 minute duration) for the 12 weeks.

Kundalini yoga and meditation

Participants will engage in weekly yoga classes and daily 20 minute meditation

Group Type: EXPERIMENTAL

Kundalini yoga and meditation

Intervention Type: BEHAVIORAL

Participants will participate in a 60 minute yoga and meditation session weekly for 12 weeks and will be assigned a daily Kirtan Kriya meditation (12 minute duration) for 12 weeks.

Interventions

Kundalini yoga and meditation

Participants will participate in a 60 minute yoga and meditation session weekly for 12 weeks and will be assigned a daily Kirtan Kriya meditation (12 minute duration) for 12 weeks.

Intervention Type: BEHAVIORAL

Memory Training

Participants will attend a weekly memory training class for 12 weeks as well as receive daily memory homework (12 minute duration) for the 12 weeks.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Mild cognitive impairment amnestic type
• Clinical Dementia Rating scale score of 0.5
• SufficientEnglish proficiency and 8th grade or higher reading level as determined by the word reading subtest of the Wide Range Achievement Test-IV
• Capacity to provide informed consent.

Exclusion Criteria

• Any current or past psychiatric disorders, or recent unstable medical or neurological disorders
• Any disabilities preventing their participation in the memory enhancement training (MET) (e.g. severe visual or hearing impairment)
• Insufficient English proficiency
• Diagnosis of dementia
• Mini Mental Health Examination score of 24 and below
• Psychoactive medications
• Participation in a psychotherapy that involves cognitive training
• Do not meet criteria for Mild cognitive impairment subtype
• Prior or current training in yoga.

• Minimum Eligible Age: 55 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of California, Los Angeles

OTHER

Sponsor Role: lead

Responsible Party

Helen Lavretsky, MD

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Helen Lavretsky, MD, MS

Role: PRINCIPAL_INVESTIGATOR

UCLA Semel Institute

Locations

UCLA Semel Institute

Los Angeles, California, United States

Countries

United States

References

Eyre HA, Siddarth P, Acevedo B, Van Dyk K, Paholpak P, Ercoli L, St Cyr N, Yang H, Khalsa DS, Lavretsky H. A randomized controlled trial of Kundalini yoga in mild cognitive impairment. Int Psychogeriatr. 2017 Apr;29(4):557-567. doi: 10.1017/S1041610216002155. Epub 2017 Jan 16.

Reference Type: DERIVED

PMID: 28088925 (View on PubMed)

Other Identifiers

13-000821

Identifier Type: -

Identifier Source: org_study_id