Comparison of Subjective Outcomes and Changes of Ultrasonographic Morphology of Median Nerves of Mini-open and Endoscopic Carpal Tunnel Release in Patients With Idiopathic Carpal Tunnel Syndrome

NCT ID: NCT01972165

Last Updated: 2013-10-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

67 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-11-30

Study Completion Date

2013-07-31

Brief Summary

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A few studies have shown that the mini-incision release technique decreases the pathologic swelling of the median nerve at the inlet of the carpal tunnel and increases the flattening ratio of the median nerve in the carpal tunnel. However, it is unknown whether the endoscopic release technique similarly reverses these pathological changes in the median nerve along the carpal tunnel in patients with CTS compared with the mini-incision release.

Investigators therefore conducted the current study to compare the subjective outcomes and US-measured morphological changes in the median nerve in patients with CTS who received either mini-incision or endoscopic release. Investigators hypothesized that (1) subjective outcomes, as assessed by both the Boston Carpal Tunnel Questionnaire (BCTQ) symptom/function scores and the DASH scores, would be similar 24 weeks after either mini-incision or endoscopic carpal tunnel release; (2) changes in the morphology of the median nerve at each level of the carpal tunnel, as measured under high-resolution US, would be similar 24 weeks after either mini-incision or endoscopic carpal tunnel release; and (3) morphological changes would be correlated with improvements in subjective outcomes 24 weeks after mini-incision or endoscopic carpal tunnel release.

Detailed Description

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Conditions

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Idiopathic Carpal Tunnel Syndrome

Keywords

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Carpal tunnel syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Group I

Mini-incision carpal tunnel release group

Group Type EXPERIMENTAL

Mini-incision carpal tunnel release

Intervention Type PROCEDURE

Group II

Endoscopic carpal tunnel release group

Group Type ACTIVE_COMPARATOR

Endoscopic carpal tunnel release

Intervention Type PROCEDURE

Interventions

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Mini-incision carpal tunnel release

Intervention Type PROCEDURE

Endoscopic carpal tunnel release

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients who are 20 years or older.
* Patients with idiopathic CTS that was confirmed by electrodiagnostic tests
* Patients with idiopathic CTS who were scheduled for carpal tunnel release

Exclusion Criteria

* Patients with a history of wrist-area fracture or dislocation
* Patients with previous carpal tunnel release
* Patients with associated cervical radiculopathy, cubital tunnel syndrome, thoracic outlet syndrome, diabetes mellitus, hypothyroidism, arthritis, or Burger's disease
* Patients with cognitive impairment that affected the patient's ability to complete the questionnaires
* Patients with worker's compensation issues
* Patients with inadequate follow-up (i.e., less than 24 weeks post-operation)
Minimum Eligible Age

27 Years

Maximum Eligible Age

82 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Yonsei University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Department of Orthopedic Surgery,Severance Hospital, Yonsei University Health System

Seoul, , South Korea

Site Status

Countries

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South Korea

References

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Oh WT, Kang HJ, Koh IH, Jang JY, Choi YR. Morphologic change of nerve and symptom relief are similar after mini-incision and endoscopic carpal tunnel release: a randomized trial. BMC Musculoskelet Disord. 2017 Feb 3;18(1):65. doi: 10.1186/s12891-017-1438-z.

Reference Type DERIVED
PMID: 28158978 (View on PubMed)

Other Identifiers

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1-2011-0072

Identifier Type: -

Identifier Source: org_study_id