Weaning From Mechanical Ventilation Guided by Lung Ultrasound (Brazilian WEANLUS)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-03-31

Study Completion Date

2019-05-31

Brief Summary

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The present study aims to evaluate the impact of a weaning strategy based on identification of early signs of respiratory distress by lung ultrasound and the consequent implementation of a "clinical optimization" protocol as compared to usual care.

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Detailed Description

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Conditions

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Acute Respiratory Failure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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usual care

Weaning as protcolised by the units' daily practice (SBT)

Group Type NO_INTERVENTION

No interventions assigned to this group

Weaning guided by lung ultrasound

Predictive early signs of respiratory distress are assessed by lung ultrasound and if found will trigger protocolised intervention (eg- fluid balance,diuretics, thoracocentesis)

Group Type EXPERIMENTAL

weaning guided by LUS (lung ultrasound)

Intervention Type OTHER

Predictive early signs of respiratory distress are assessed by lung ultrasound (LUS score \>14) and if present will trigger protocolised intervention (eg- fluid balance,diuretics, thoracocentesis, antibiotics when required \[CPIS\>6\], hemglobin\>8g/dl triggers transfusion)

Interventions

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weaning guided by LUS (lung ultrasound)

Predictive early signs of respiratory distress are assessed by lung ultrasound (LUS score \>14) and if present will trigger protocolised intervention (eg- fluid balance,diuretics, thoracocentesis, antibiotics when required \[CPIS\>6\], hemglobin\>8g/dl triggers transfusion)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Mechanically ventilated \>48h

Exclusion Criteria

* Moderate/Severe COPD
* Spinal cord lesion
* Neuromuscular disease (previous)
* Lung fibrosis
* Tracheostomy
* Heart failure (EF\<50%)
* Lung/pleural cancer
* inadequate "window"for LUS

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No