Trial of Hemodialysis Based Exercise for Strength Improvement Study
NCT ID: NCT01962597
Last Updated: 2016-04-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
60 participants
INTERVENTIONAL
2013-10-31
2017-09-30
Brief Summary
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Brief Summary:
Sixty hemodialysis participants who meet inclusion and exclusion criteria will be randomized to 20 weeks of supervised exercise, using either: (i) on-dialysis aerobic exercise using a bike ergometer; (ii) pre-dialysis leg strength training using weights; or (iii) both. The primary outcome is walking speed over 4-metres. Secondary outcomes will include:
(i) short physical performance battery; (ii) health-related quality of life \[EuroQOL-5D-5L\]; (iii) Dialysis recovery time; (iv) Nottingham extended activities of daily living (EADL) index; (v) Leg strength; (vi) body composition and anthropometry.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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aerobic exercise
patients will undergo supervised exercise on a bike ergometer for 30 minutes three times per week during hemodialysis
aerobic exercise
resistance training
patients will undergo supervised lower extremity strength training three times per week pre-hemodialysis
resistance training
aerobic exercise and resistance training
patients will undergo a combination of aerobic exercise and resistance training on an alternating schedule three time per week
aerobic exercise
resistance training
Interventions
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aerobic exercise
resistance training
Eligibility Criteria
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Inclusion Criteria
* On hemodialysis minimum of 3 times per week
* On hemodialysis \> 3 consecutive months
Exclusion Criteria
* Inability to walk 4-metres
* Chest pain with exertion or myocardial infarction in past 6-months
* Pre-dialysis systolic blood pressure \> 200 mm Hg or diastolic BP \> 100 mm Hg in past 2-weeks
* Functional or cardiorespiratory limitations preventing use of cycle ergometer for at least five-minutes or the ability to perform single maximum rep with each of resistance exercises described
* Joint replacement or lower extremity fracture in previous 6-months
* Severe cognitive impairment
* Currently using corticosteroids \>5 mg/day
* Pre-dialysis serum potassium in previous month less than 3.5 or greater than 6.0 mmol/L.
* Attending nephrologist feels exercise is medically contraindicated
* Scheduled living related kidney transplant in next 6 months
18 Years
ALL
No
Sponsors
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St. Joseph's Healthcare Hamilton
OTHER
Responsible Party
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Scott Brimble
Staff Nephrologist/Associate Professor of Medicine
Locations
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St. Josephs Healthcare Hamilton
Hamilton, Ontario, Canada
Countries
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Other Identifiers
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13-468
Identifier Type: -
Identifier Source: org_study_id
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