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The Effects of L-Arabinose and D-xylose on Intestinal Sucrase Activity in Man

NCT ID: NCT01957098

Last Updated: 2013-10-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

14 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-10-31

Study Completion Date

2007-05-31

Brief Summary

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The purpose of this study is to investigate the effect of L-arabinose and D-xylose in a sugar-rich drink on intestinal sucrase activity in healthy volunteers by measuring postprandial blood glucose and insulin, and selected intestinal hormonal responses to increasing doses of L-arabinose and D-xylose.

Detailed Description

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Based on previous scientific results we hypotesize, that pentoses decreases the demand for insulin in metabolizing a given dose of sucrose.

Conditions

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Insulin Resistance

Keywords

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L-arabinose D-xylose sucrose glucose insulin C-peptide GLP-1

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

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0% pentose

Pure sucrose without pentoses added.

Group Type PLACEBO_COMPARATOR

Placebo comparator: 0% pentose

Intervention Type DIETARY_SUPPLEMENT

14 healthy subjects participated in a randomized double-blinded cross-over study based on four single tests. Sucrose containing drinks were supplemented with two different doses of D-xylose and in addition one dose of L-arabinose was included for comparison with earlier studies. Blood was collected fasting and for 3-h postprandially. Appetite sensations and energy intake were registered. Gastrointestinal symptoms were monitored for 24 hours

4% D-xylose

Sucrose drink supplemented with 4% D-xylose

Group Type ACTIVE_COMPARATOR

Active comparator: 4% D-xylose

Intervention Type DIETARY_SUPPLEMENT

8% D-xylose

Sucrose drink supplemented with 8% D-xylose

Group Type ACTIVE_COMPARATOR

Active comparator: 8% D-xylose

Intervention Type DIETARY_SUPPLEMENT

8% L-arabinose

Sucrose drink supplemented with 8% L-arabinose

Group Type ACTIVE_COMPARATOR

Active comparator: 8% L-arabinose

Intervention Type DIETARY_SUPPLEMENT

Interventions

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Placebo comparator: 0% pentose

14 healthy subjects participated in a randomized double-blinded cross-over study based on four single tests. Sucrose containing drinks were supplemented with two different doses of D-xylose and in addition one dose of L-arabinose was included for comparison with earlier studies. Blood was collected fasting and for 3-h postprandially. Appetite sensations and energy intake were registered. Gastrointestinal symptoms were monitored for 24 hours

Intervention Type DIETARY_SUPPLEMENT

Active comparator: 4% D-xylose

Intervention Type DIETARY_SUPPLEMENT

Active comparator: 8% D-xylose

Intervention Type DIETARY_SUPPLEMENT

Active comparator: 8% L-arabinose

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* healthy males
* BMI between 18.4-25 kg/m2
* age between 18 and 30

Exclusion Criteria

* donation of blood 3 months before or during the study
* gastrointestinal disorders, diabetes, hypertension, hyperlipidemia, chronic infectious disease (HIV or hepatitis)
* smoking
* consumption of more than 21 alcoholic drinks/week
* elite athletes
* on medication
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Danisco

INDUSTRY

Sponsor Role collaborator

University of Copenhagen

OTHER

Sponsor Role lead

Responsible Party

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AAstrup

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jens R Andersen, MD,MPA

Role: STUDY_CHAIR

Department of Nutrition, Exercise and sports, University of Copenhagen

Locations

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Institute of Human Nutrition, The Royal Veterinary and Agricultural University

Frederiksberg, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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(KF) 11 324909

Identifier Type: -

Identifier Source: org_study_id