Randomized Comparison of Continuous and Intermittent Heparin Infusion During Catheter Ablation of Atrial Fibrillation
NCT ID: NCT01935557
Last Updated: 2016-04-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
296 participants
INTERVENTIONAL
2012-12-31
2015-12-31
Brief Summary
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Randomized comparison of continuous and intermittent heparin infusion during catheter ablation of Atrial Fibrillation.
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Detailed Description
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heparin is administered during the procedure to achieve recommended activation clotting times (ACT) values, typically \>300 seconds to prevent thromboemboli during the procedure.
Most of the practitioners was that ACT level should be checked at 30- to 60-minute intervals and then have injected intermittently.
intermittent heparin infusion, concentration is great changed because the heparin has 30minutes half-period.
researchers postulate that a constant therapeutic concentrations would be beneficial to continuous infusion than intermittent infusion.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Continuous heparin infusion group
continuous group is given an initial intravenous heparin 100u/kg and then maintain heparin infusion during procedural.
Continuous heparin infusion
continuous group is given an initial intravenous heparin 100u/kg and then maintain heparin infusion during procedural.
Intermittent heparin infusion group
Intermittent group is given an initial intravenous heparin 100u/kg. Then The ACT is tested every 30min with administration of additional heparin boluses and titration of the heparin drip based on the results and according to the judgment of the operating physician.
Intermittent heparin infusion
Intermittent group is given an initial intravenous heparin 100u/kg. Then The ACT is tested every 30min with administration of additional heparin boluses and titration of the heparin drip based on the results and according to the judgment of the operating physician.
Interventions
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Continuous heparin infusion
continuous group is given an initial intravenous heparin 100u/kg and then maintain heparin infusion during procedural.
Intermittent heparin infusion
Intermittent group is given an initial intravenous heparin 100u/kg. Then The ACT is tested every 30min with administration of additional heparin boluses and titration of the heparin drip based on the results and according to the judgment of the operating physician.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
ALL
No
Sponsors
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Yong Seog Oh
OTHER
Responsible Party
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Yong Seog Oh
Professor
Principal Investigators
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Yong Seog Oh, MD
Role: PRINCIPAL_INVESTIGATOR
Seoul St. Mary's Hospital
Locations
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Seoul st. mary's hospital
Seoul, , South Korea
Countries
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References
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Kim TS, Kim SH, Kim BK, Kim JY, Kim JH, Jang SW, Lee MY, Rho TH, Oh YS. Randomized Comparison of Continuous Versus Intermittent Heparin Infusion During Catheter Ablation of Atrial Fibrillation. JACC Clin Electrophysiol. 2016 Jun;2(3):319-326. doi: 10.1016/j.jacep.2015.11.004. Epub 2015 Dec 9.
Other Identifiers
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COHERE
Identifier Type: -
Identifier Source: org_study_id
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