Mindfulness Intervention to Study the Neurobiology of Depression
NCT ID: NCT01905267
Last Updated: 2018-07-30
Study Results
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View full resultsBasic Information
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COMPLETED
NA
33 participants
INTERVENTIONAL
2013-03-31
2017-06-30
Brief Summary
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Detailed Description
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* Brain scan using fMRI technology
* Questions about mood and behavior
* Meeting with a clinician
* Possibility of 8 weekly treatment sessions using mindfulness
* Ongoing assessment of depression for next 2 years
Eligible participants will be compensated for their time.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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Treatment
Participants randomized to the experimental condition will receive 8 weeks of individual treatment with Rumination-Focused Cognitive Behavior Therapy
Rumination-Focused Cognitive Behavior Therapy
This intervention targets rumination and other maladaptive forms of emotion regulation such as suppression and avoidance and provides skills training in effective coping strategies. Mindfulness is a key component of this intervention as a strategy for disengaging from one's thoughts. Strategies from Dialectical Behavior Therapy (DBT), such as the use of effective interpersonal skills, are also included as methods for regulating strong emotion. Rumination-Focused Cognitive Behavior Therapy is a structured, manual based program designed to be delivered weekly over eight weeks. Sessions are 60-90 minutes in length.
Control
Participants randomized to the control arm will complete questionnaires and receive mood monitoring for the duration of the study
No interventions assigned to this group
Interventions
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Rumination-Focused Cognitive Behavior Therapy
This intervention targets rumination and other maladaptive forms of emotion regulation such as suppression and avoidance and provides skills training in effective coping strategies. Mindfulness is a key component of this intervention as a strategy for disengaging from one's thoughts. Strategies from Dialectical Behavior Therapy (DBT), such as the use of effective interpersonal skills, are also included as methods for regulating strong emotion. Rumination-Focused Cognitive Behavior Therapy is a structured, manual based program designed to be delivered weekly over eight weeks. Sessions are 60-90 minutes in length.
Eligibility Criteria
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Inclusion Criteria
* history of major depressive disorder
Exclusion Criteria
* afraid of small spaces
12 Years
18 Years
ALL
No
Sponsors
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University of Illinois at Chicago
OTHER
Responsible Party
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Rachel Jacobs
Research Assistant Professor, Licensed Clinical Psychologist
Principal Investigators
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Rachel H Jacobs, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Illinois at Chicago
Locations
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University of Illinois at Chicago Pediatric Mood Disorders Program
Chicago, Illinois, United States
Countries
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References
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Bessette KL, Jacobs RH, Heleniak C, Peters AT, Welsh RC, Watkins ER, Langenecker SA. Malleability of rumination: An exploratory model of CBT-based plasticity and long-term reduced risk for depressive relapse among youth from a pilot randomized clinical trial. PLoS One. 2020 Jun 17;15(6):e0233539. doi: 10.1371/journal.pone.0233539. eCollection 2020.
Jacobs RH, Watkins ER, Peters AT, Feldhaus CG, Barba A, Carbray J, Langenecker SA. Targeting Ruminative Thinking in Adolescents at Risk for Depressive Relapse: Rumination-Focused Cognitive Behavior Therapy in a Pilot Randomized Controlled Trial with Resting State fMRI. PLoS One. 2016 Nov 23;11(11):e0163952. doi: 10.1371/journal.pone.0163952. eCollection 2016.
Provided Documents
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Document Type: Informed Consent Form
Document Type: Study Protocol
Document Type: Statistical Analysis Plan
Other Identifiers
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2012-0689
Identifier Type: -
Identifier Source: org_study_id
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