Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
32 participants
OBSERVATIONAL
2013-07-31
2017-06-30
Brief Summary
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The study hypothesis is that Magnetic Resonance Imaging will provide a more accurate assessment of tumour volume and local staging than CT and will identify areas of altered oxygenation, cellularity and perfusion which change in response to radiotherapy before tumour shrinkage occurs.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Curative intent surgery alone
Patients with retroperitoneal sarcoma randomised into surgery alone arm.
Magnetic Resonance Imaging
Pre-operative radiotherapy plus surgery
Patients with retroperitoneal sarcoma randomised to Arm 2: pre-operative radiotherapy plus surgery.
Magnetic Resonance Imaging
Interventions
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Magnetic Resonance Imaging
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* claustrophobia
18 Years
80 Years
ALL
No
Sponsors
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Royal Marsden NHS Foundation Trust
OTHER
Cancer Research UK
OTHER
Institute of Cancer Research, United Kingdom
OTHER
Responsible Party
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Nandita deSouza
Professor of Translational Imaging
Locations
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The Royal Marsden NHS Foundation Trust
Sutton, Surrey, United Kingdom
Countries
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References
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Winfield JM, Miah AB, Strauss D, Thway K, Collins DJ, deSouza NM, Leach MO, Morgan VA, Giles SL, Moskovic E, Hayes A, Smith M, Zaidi SH, Henderson D, Messiou C. Utility of Multi-Parametric Quantitative Magnetic Resonance Imaging for Characterization and Radiotherapy Response Assessment in Soft-Tissue Sarcomas and Correlation With Histopathology. Front Oncol. 2019 Apr 25;9:280. doi: 10.3389/fonc.2019.00280. eCollection 2019.
Other Identifiers
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13/EE/0186 CCR3992
Identifier Type: -
Identifier Source: org_study_id
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