Auditory Verbal Hallucinations in Schizophrenia

NCT ID: NCT01886417

Last Updated: 2015-03-10

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 40 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2009-10-31
• Study Completion Date: 2015-03-31

Brief Summary

Auditory verbal hallucinations (AVHs) are speech perceptions in the absence of a relevant external stimulation. Some accounts of AVHs claim that a deficit in inner speech monitoring would cause the verbal thoughts of the patient to be perceived as external voices resulting in AVHs.

In order to examine whether AVHs correspond to self-generated inner speech, the present study aims at collecting speech muscle activity during covert AVHs (without articulation), overt speech and rest. Surface electromyography (sEMG) is used on schizophrenia patients and control subjects to detect any speech muscle activity during AVH.

Conditions

Schizophrenia

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

Healthy controls:

• must be more than 18 years and less than 60 years old
• pre-inclusion medical examination
• must have signed consent form
• must be able to read stimuli on a screen

Schizophrenia patients:

• must be more than 18 years and less than 60 years old
• pre-inclusion medical examination
• must have signed consent form
• must be able to read stimuli on a screen
• diagnosed with a schizophrenia disorder according to DSM-IV TR (diagnostic and statistical of mental disorders) (PANSS item P3 greater than 4)
• prior evaluation of the secondary effects of any medication via Barnes and AIMS scales
• affiliated with the French social security
• if under guardianship, must have additional consent form signed by guardian

Exclusion Criteria

Healthy controls:

• if aged less than 18 years or more than 60 years
• diagnosed with any psychiatric disorder
• with any language disorder (aphasia, SLI, dysarthria, stuttering, etc.)
• with auditory impairment
• pregnant, parturient, breast-feeding

Schizophrenia patients:

• if aged less than 18 years or more than 60 years
• significant secondary effects of antipsychotic medication, measured with the Barnes and AIMS scales
• with a neurodegenerative disease
• with any language disorder (aphasia, SLI, dysarthria, stuttering, etc.)
• with auditory impairment
• pregnant, parturient, breast-feeding

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

GIPSA-LAB

OTHER

Sponsor Role: collaborator

University Hospital, Grenoble

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Thierry BOUGEROL, MD, PHD, HDR

Role: PRINCIPAL_INVESTIGATOR

University Hospital of Grenoble, France

Locations

University Hospital of Grenoble

Grenoble, , France

Countries

France

Other Identifiers

2009-A00248-49

Identifier Type: REGISTRY

Identifier Source: secondary_id

0906

Identifier Type: -

Identifier Source: org_study_id