A Case Control Study of the Prevalence of Pulmonary Hypertension in Patients With Myeloproliferative Diseases.

NCT ID: NCT01884974

Last Updated: 2015-06-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-07-31

Brief Summary

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Pulmonary hypertension (PH) is defined as a group of diseases characterised by an elevated mean pulmonary artery pressure (Ppa) ≥25 mmHg at rest. Recently, chronic myeloproliferative diseases (CMPD) associated with pulmonary hypertension were included in the group 5 category, corresponding to PH for which the aetiology is unclear and/or multifactorial. CMPD include chronic myelogenous leukaemia, chronic neutrophilic leukaemia and chronic eosinophilic leukaemia (which primarily express a myeloid phenotype and polycythaemia vera), idiopathic myelofibrosis, and essential thrombocytosis in which erythroid or megakaryocytic hyperplasia predominates.

The purpose of this research:

1. Assess Prevalence of PH in patients with CMPD in Northern Israel
2. Describe the demographics and clinical course in patients with CMPD who are diagnosed with PH.

Detailed Description

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study will include the following:

* sex
* age
* BMI
* ethnicity
* age diagnosed with Myeloproliferative disease
* clinical manifestations of the myeloproliferative disease
* JAK2 mutation
* known hematological complications

Conditions

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Myeloproliferative Disease Pulmonary Hypertension

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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myeloproliferative disease

Patients with Myeloproliferative Diseases as specified under inclusion and exclusion criteria

myeloproliferative disease

Intervention Type OTHER

Echocardiogram, demographic data, St George respiratory questioner

Interventions

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myeloproliferative disease

Echocardiogram, demographic data, St George respiratory questioner

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1\) consenting patients diagnosed with a myeloproliferative disease

Exclusion Criteria

1\) Refusal to have an echocardiogram or answer the St. George respiratory questionnaire
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Carmel Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Shoshan Perek

Dr Shoshan Perek

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Shoshan Perek, MD

Role: PRINCIPAL_INVESTIGATOR

Carmel Medical Center

Locations

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Pulmonology Institute, Carmel Medical Center

Haifa, , Israel

Site Status RECRUITING

Countries

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Israel

Central Contacts

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Shoshan Perek, MD

Role: CONTACT

972-4-8250517

Facility Contacts

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Shoshan Perek, MD

Role: primary

972-4-8250517

Other Identifiers

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CMC-12-0060-CTIL

Identifier Type: -

Identifier Source: org_study_id

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