Evaluation and Management of Cardiovascular Risk Factors in Inflammatory and Acquired Dysimmune Diseases (CARMIN)

NCT ID: NCT02835547

Last Updated: 2016-07-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-02-28

Study Completion Date

2015-08-31

Brief Summary

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The hypothesis is that chronic inflammatory dysimmune state promotes the development of cardiovascular complications. The biological assumption is based on the fact that chronic inflammation promotes lesions of the vessel wall (endothelial alterations, calcification, atherosclerosis). The clinical aim is to allow to identify high-risk patients and to act in prevention.

The project CARMIN involves the assessment of cardiovascular risk factors, their management, and their influence on cardiovascular prognosis in patients with autoimmune diseases and immunodeficiencies acquired. It is based on the creation and monitoring of a cohort of patients with different types of dysimmune disorders: systemic lupus erythematosus, rheumatoid arthritis, psoriasis, scleroderma, systemic vasculitis ANCA, kidney transplants, and hematopoietic stem cells transplants.

Detailed Description

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Conditions

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Inflammatory and Acquired Dysimmune Diseases

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Systemic lupus erythematosus

Data collection of risk factors (collected retrospectively - 5 years) and cardiovascular events (collected prospectively - 2 years).

Data collection

Intervention Type OTHER

Risk factors will be collected retrospectively (5 years) and cardiovascular events prospectively (2 years)

Rheumatoid arthritis

Data collection of risk factors (collected retrospectively - 5 years) and cardiovascular events (collected prospectively - 2 years).

Data collection

Intervention Type OTHER

Risk factors will be collected retrospectively (5 years) and cardiovascular events prospectively (2 years)

Psoriasis

Data collection of risk factors (collected retrospectively - 5 years) and cardiovascular events (collected prospectively - 2 years).

Data collection

Intervention Type OTHER

Risk factors will be collected retrospectively (5 years) and cardiovascular events prospectively (2 years)

Scleroderma

Data collection of risk factors (collected retrospectively - 5 years) and cardiovascular events (collected prospectively - 2 years).

Data collection

Intervention Type OTHER

Risk factors will be collected retrospectively (5 years) and cardiovascular events prospectively (2 years)

Hematopoietic stem cells transplants

Data collection of risk factors (collected retrospectively - 5 years) and cardiovascular events (collected prospectively - 2 years).

Data collection

Intervention Type OTHER

Risk factors will be collected retrospectively (5 years) and cardiovascular events prospectively (2 years)

Kidney transplants

Data collection of risk factors (collected retrospectively - 5 years) and cardiovascular events (collected prospectively - 2 years).

Data collection

Intervention Type OTHER

Risk factors will be collected retrospectively (5 years) and cardiovascular events prospectively (2 years)

Interventions

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Data collection

Risk factors will be collected retrospectively (5 years) and cardiovascular events prospectively (2 years)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients followed in the various services of medical specialties pole of the Edouard Herriot hospital
* The diagnosis of the pathology selected for this study based on a clear clinical and biological evaluation supported by criteria specific to each pathology and compatible with international standards.
* Date of diagnosis should not be less than 5 years (+/- 1 year), except for scleroderma patients where it has been extended to 10 years.
* For kidney transplant patients the investigators take into account only patients with a maximum of 2 years of dialysis before graft.

Exclusion Criteria

* Diabetic patients
* HIV seropositive
* Patients with multiple pathologies
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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D50841

Identifier Type: -

Identifier Source: org_study_id

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