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Mechanisms of Myocardial Infarction in Women With Non Obstructive Coronary Artery Disease

NCT ID: NCT01953029

Last Updated: 2013-09-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-12-31

Study Completion Date

2018-10-31

Brief Summary

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The objective of our work to determine the mechanisms of myocardial infarction in women without obstructive coronary artery disease.

Detailed Description

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Cardiovascular disease is the leading cause of death for women. Acute coronary syndrome (ACS) is usually characterized by a sudden erosion of the endothelial wall or rupture of a plaque.However, women with ACS are less likely than men to have either classic symptoms or obstructive coronary artery disease but paradoxically have a worse prognosis. Different data from the literature indicate that there may be different pathophysiological mechanisms, afflicting men and women somewhat differently.Between 5% and 30% of patients with ACS undergoing coronary angiography are found to have non visible or non obstructive coronary disease (NOCD). This is 2-3 times more common in women than in men. Several pathogenetic mechanism of myocardial infarction (MI) in the absence of obstructive coronary artery disease (OCD) have been postulated, including among others atherosclerosis with plaque disruption that does not lead to luminal occlusion ,endothelial dysfunction, vasospasm , distal microembolization and microvascular dysfunction. However the data are extremely limited.

Conditions

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Myocardial Infarction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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non obstructive coronary disease

non obstructive coronary disease

cardiac imajing

Intervention Type PROCEDURE

Cardiac MRI

Interventions

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cardiac imajing

Cardiac MRI

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Women ≥ 18 years old, not pregnant
* with acute non ST elevation myocardial infarction (admitted within 12 hours from beginning of symptoms)
* who are candidates for coronary arteriography during the hospitalization. -

Exclusion Criteria

\*Women with troponin elevation caused by other causes -
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Rambam Health Care Campus

OTHER

Sponsor Role lead

Responsible Party

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Miry Blich MD

Senior Cardiologist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Miry Blich, MD

Role: PRINCIPAL_INVESTIGATOR

Rambam Health Care Campus

Locations

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Rambam Heath Care Campus

Haifa, , Israel

Site Status

Countries

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Israel

Central Contacts

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Miry Blich, MD

Role: CONTACT

Phone: 972-4-8543478

Email: [email protected]

Facility Contacts

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Miry Blich, MD

Role: primary

Other Identifiers

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0541-12-RMB

Identifier Type: -

Identifier Source: org_study_id