Use of Proteomics for the Diagnosis of a Platelet-related Bleeding Disorder

NCT ID: NCT02096523

Last Updated: 2021-08-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

4 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-11-30

Study Completion Date

2021-07-31

Brief Summary

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The goal of this study is to identify the platelet defect responsible for the bleeding in families from our inherited platelet disorders Israeli-Palestinian registry. The investigators plan to characterize platelet proteome expression after removing high abundance proteins. The investigators will compare the proteome of sick and healthy members of families with inherited platelet disorders, and identify and validate structural proteins, signaling cascades and biomarkers for detection and diagnosis of unknown platelet disorders. The investigators expect to discover new key findings that allow better understanding of human platelet function and allow better diagnosis and treatment of patients with inherited platelet function disorders.

Detailed Description

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Conditions

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Inherited Platelet Disorders

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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platelet disease

patients with inherited platelet disorders

Group Type EXPERIMENTAL

Blood collection for platelet protein samples

Intervention Type OTHER

Healthy

Healthy family members of patients with inherited platelet disorders

Group Type EXPERIMENTAL

Blood collection for platelet protein samples

Intervention Type OTHER

Interventions

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Blood collection for platelet protein samples

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* History of inherited platelet disorders in the family

Exclusion Criteria

* none
Minimum Eligible Age

3 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ela Shai

OTHER

Sponsor Role lead

Responsible Party

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Ela Shai

Researcher at Hadassah Medical Center

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Hadassah Medical Organization

Jerusalem, , Israel

Site Status

Countries

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Israel

Other Identifiers

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002714- HMO-CTIL

Identifier Type: -

Identifier Source: org_study_id

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