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Protein S100 Beta as a Predictor of Resuscitation Outcome

NCT ID: NCT00814814

Last Updated: 2020-11-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

313 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-02-29

Study Completion Date

2021-11-30

Brief Summary

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Management of cardiac arrest is complicated by the lack of a readily available tool identifying individuals who are likely to be successfully resuscitated. S100 beta is a protein that originates in the astroglial cells of the brain, and NSE (Neuron Specific Enolase) is another protein that originates in the neurons themselves. In the laboratory, the concentration of these proteins correlate with evidence of brain damage after head trauma, stroke and exposure to low levels of oxygen. The concentration of these proteins in the blood of human survivors of cardiopulmonary resuscitation in humans is much higher than in patients who were resuscitated but did not survive. However, it is still unclear whether survivors from cardiopulmonary resuscitation have higher levels of these proteins in their blood if they survive with neurological injury secondary to the arrest and resuscitation.

Hypothesis: In humans, the blood concentrations of protein S100 beta and NSE during and after resuscitation can predict who will die despite cardiopulmonary resuscitation and who will survive with neurological injury secondary to the arrest and resuscitation.

Detailed Description

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Conditions

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Cardiopulmonary Arrest Outcome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

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Cardiopulmonary arrest

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* All victims of non-traumatic out-of hospital cardiopulmonary arrest (defined as the absence of either spontaneous respiration or palpable pulse or both) within the Jerusalem district.

Exclusion Criteria

* Patients with do-not-resuscitate orders or an advance directive to that effect.
* Patients with intracranial hemorrhage
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shaare Zedek Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Dr Sharon Einav

Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sharon Einav, MD

Role: PRINCIPAL_INVESTIGATOR

Shaare Zedek Medical Center

Locations

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Shaare Zedek Medical Center

Jerusalem, , Israel

Site Status

Hadassah Medical Center

Jerusalem, , Israel

Site Status

Countries

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Israel

References

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Einav S, Kaufman N, Algur N, Strauss-Liviatan N, Kark JD. Brain biomarkers and management of uncertainty in predicting outcome of cardiopulmonary resuscitation: a nomogram paints a thousand words. Resuscitation. 2013 Aug;84(8):1083-8. doi: 10.1016/j.resuscitation.2013.01.031. Epub 2013 Feb 4.

Reference Type RESULT
PMID: 23391666 (View on PubMed)

Einav S, Kaufman N, Algur N, Kark JD. Modeling serum biomarkers S100 beta and neuron-specific enolase as predictors of outcome after out-of-hospital cardiac arrest: an aid to clinical decision making. J Am Coll Cardiol. 2012 Jul 24;60(4):304-11. doi: 10.1016/j.jacc.2012.04.020.

Reference Type RESULT
PMID: 22813607 (View on PubMed)

Other Identifiers

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14-01-05 A and B (correction)

Identifier Type: -

Identifier Source: org_study_id