Effects of Standing on Glycemia in Prediabetic Adults

NCT ID: NCT01884792

Last Updated: 2014-09-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-03-31

Study Completion Date

2013-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The study is a crossover, pilot trial examining the acute effects of standing on blood sugar in prediabetic, working adults. Participants will complete oral glucose tolerance testing, once while sitting and once while standing. They will also wear a continuous blood sugar monitor once while sitting at their desk for a week and once while using their desk as a sit-stand desk with a goal of standing intermittently for at least half of the work day. Physical activity levels will be measured with an accelerometer. The primary study hypothesis is that blood sugar will differ between the sitting and standing conditions for each of the tests performed.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Prediabetes

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Sitting Oral Glucose Tolerance Test

An OGTT is performed while the subject sits at their desk for the entire 2-hour period. 5 blood sugar measurements are taken and a 75g dextrose beverage is consumed following the first, baseline blood sugar reading. The blood sugar is then measured every 30 minutes up to 120 min.

Group Type PLACEBO_COMPARATOR

Sitting OGTT

Intervention Type OTHER

Standing OGTT

Intervention Type OTHER

Standing Oral Glucose Tolerance Test

The participant stands at their desk for the duration of the 2-hour blood sugar test. The same procedure is performed as in the sitting condition.

Group Type EXPERIMENTAL

Sitting OGTT

Intervention Type OTHER

Standing OGTT

Intervention Type OTHER

Sitting Continuous Glucose Monitor

A continuous blood glucose monitor is worn for 5 days while at work. In the sitting condition the participant only sits at their desk for the duration of the week. Blood sugar is monitored 4 times per day to calibrate the CGM and an accelerometer is worn to track physical activity.

Group Type PLACEBO_COMPARATOR

Sitting CGM

Intervention Type OTHER

Standing CGM

Intervention Type OTHER

Standing Continuous Glucose Monitor

Participants are instructed to stand intermittently for at least half of their work day during this 5 day period. Blood sugar is monitored and physical activity is tracked with an accelerometer.

Group Type EXPERIMENTAL

Sitting CGM

Intervention Type OTHER

Standing CGM

Intervention Type OTHER

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Sitting OGTT

Intervention Type OTHER

Standing OGTT

Intervention Type OTHER

Sitting CGM

Intervention Type OTHER

Standing CGM

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Fasting blood glucose \>100 mg/dl
* Employed full-time working at least 35 hours/week
* Able to safely begin a light physical activity program

Exclusion Criteria

* Heart disease
* Renal disease
* Peripheral neuropathy
* Retinopathy
* PAD
* Lower limb amputation
* pregnancy
* active substance abuse
* current smoker
* psychiatric disorder
* severe visual impairment
* immune-compromised individuals,
* enrollment in a physical activity study
* use of insulin or an insulin pump
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Mayo Clinic

OTHER

Sponsor Role collaborator

University of Minnesota

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Department of Human Services

Saint Paul, Minnesota, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

1208M18741

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Metabolic Wellness and CGM
NCT06790472 ENROLLING_BY_INVITATION