A Prospective Study of Prophylactic Gastrostomy in Head and Neck Cancer Patients Undergoing Chemoradiotherapy

NCT ID: NCT01876693

Last Updated: 2016-03-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

95 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-05-31

Study Completion Date

2015-06-30

Brief Summary

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The purpose of the study is to determine whether prophylactic gastrostomy leads to less treatment interruption and provide better quality of life in head and neck cancer patients receiving chemoradiotherapy.

Detailed Description

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Nutritional status is one of the essential factor to determine outcome of chemoradiotherapy in head and neck cancer patients. Almost all these patients develop mucositis during the treatment, which usually leads to treatment interruptions and affects the efficacy of the treatment. Prophylactic gastrostomy has been accepted for these patients with improvement of quality of life. However, there is no prospective study confirming superiority of such treatment.

The investigators enrolled head and neck cancer patients who had the plan of chemoradiotherapy. The patients will be informed about both treatment arms and will decide the arm that they preferred. The treatment interruptions, body weight and nutritional status will be assessed every 2 weeks during treatment period.

Conditions

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Carcinoma, Squamous Cell of Head and Neck

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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control

nutrition counselling with nasogastric tube insertion in the cases of weight loss more than 10% or severe mucositis developed during chemoradiotherapy

Group Type NO_INTERVENTION

No interventions assigned to this group

prophylactic percutaneous gastrostomy

prophylactic percutaneous gastrostomy with nutrition counselling

Group Type EXPERIMENTAL

prophylactic percutaneous gastrostomy

Intervention Type PROCEDURE

prophylactic percutaneous gastrostomy with nutrition counselling

Interventions

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prophylactic percutaneous gastrostomy

prophylactic percutaneous gastrostomy with nutrition counselling

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* pathologically confirmed of head and neck cancer
* plan to have chemoradiotherapy session
* Performance status of 0-2

Exclusion Criteria

* contraindications for percutaneous gastrostomy, eg coagulopathy, obstructed tumor
* Body mass index less than 16 kg/m2
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mahidol University

OTHER

Sponsor Role lead

Responsible Party

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suthinee ithimakin

Assistant professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Suthinee Ithimakin, MD

Role: PRINCIPAL_INVESTIGATOR

Siriraj Hospital

Locations

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Division of medical oncology, department of medicine Siriraj Hospital

Bangkok, , Thailand

Site Status

Countries

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Thailand

References

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Pramyothin P, Manyanont S, Trakarnsanga A, Petsuksiri J, Ithimakin S. A prospective study comparing prophylactic gastrostomy to nutritional counselling with a therapeutic feeding tube if required in head and neck cancer patients undergoing chemoradiotherapy in Thai real-world practice. J Hum Nutr Diet. 2016 Dec;29(6):768-776. doi: 10.1111/jhn.12377. Epub 2016 Mar 29.

Reference Type DERIVED
PMID: 27028666 (View on PubMed)

Other Identifiers

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si041/2013

Identifier Type: -

Identifier Source: org_study_id

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