Prediction of Drug Response in Gastric Cancer Based on 3D Bioprinting

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-10-01

Study Completion Date

2025-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The therapeutic regimens for adjuvant and neoadjuvant chemotherapy in gastric cancer (GC) predominantly hinge on clinical experience. Consequently, there is an imperative need for preclinical models to facilitate the guidance of individualized medicine. The investigators plan to establish three-dimensional (3D) bioprinted GC models derived from surgically resected tumor tissues of GC patients. These in vitro 3D models will be subjected to treatment with the identical chemotherapy drugs administered to the corresponding patients from whom the models are sourced. The sensitivity of the chemotherapy drugs will be assayed within the in vitro models, and the actual response to chemotherapy in patients will be meticulously evaluated. This observational study aims to substantiate the potential utility of 3D bioprinted tumor models in prognosticating the response to chemotherapy in GC.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

3D Bioprinted Models for Predicting Chemotherapy Response in Colorectal Cancer With/Without Liver Metastases

NCT04755907

Colorectal Cancer Colorectal Cancer Liver Metastasis

UNKNOWN

Application of 3D Printing Technique in Radical Gastrectomy With Leonardo da Vinci Robot

NCT03599895

Stomach Neoplasms

UNKNOWN NA

Biomarkers for Predicting Neoadjuvant Chemoradio-resistance for Middle-low Advanced Rectal Cancer

NCT03573791

Rectal Cancer Cancer of Rectum Cancer of the Rectum +4 more

RECRUITING

Laparoscopic Staging for Locally Advanced Gastric Cancer in Chinese Patients

NCT02172690

Gastric Cancer Peritoneal Metastases

COMPLETED NA

High Dose Rate Interstitial Brachytherapy With Three Dimensional Printing Template for Recurrent Gynecologic Tumors

NCT04127435

Cervical Cancer

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

STOMACH NEOPLASM

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Group A

gastric cancer patients at resectable stage II/III who will receive adjuvant chemotherapy after surgery

surgical resection

Intervention Type PROCEDURE

Surgical resection will be performed for locoregional lesions .

Adjuvant chemotherapy

Intervention Type OTHER

Regimens of adjuvant chemotherapy are directed by clinical guidance and experience.

Group B

gastric cancer patients at locally advanced stage who will receive neoadjuvant chemotherapy before surgery and adjuvant chemotherapy after surgery

surgical resection

Intervention Type PROCEDURE

Surgical resection will be performed for locoregional lesions .

Adjuvant chemotherapy

Intervention Type OTHER

Regimens of adjuvant chemotherapy are directed by clinical guidance and experience.

neoadjuvant therapy

Intervention Type OTHER

Regimens of neoadjuvant chemotherapy are directed by clinicalguidance and experience

Group C

Gastric cancer patients who are not scheduled to undergo neoadjuvant chemotherapy prior to surgical intervention and who will not receive adjuvant chemotherapy during the postoperative follow-up period.

surgical resection

Intervention Type PROCEDURE

Surgical resection will be performed for locoregional lesions .

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

surgical resection

Surgical resection will be performed for locoregional lesions .

Intervention Type PROCEDURE

Adjuvant chemotherapy

Regimens of adjuvant chemotherapy are directed by clinical guidance and experience.

Intervention Type OTHER

neoadjuvant therapy

Regimens of neoadjuvant chemotherapy are directed by clinicalguidance and experience

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* More than 18 years old
* Patients previously diagnosed with gastric cancer or confirmed by pathology as having gastric cancer postoperatively.
* Patients who have undergone preoperative imaging examinations, including plain and contrast-enhanced CT scans of the chest, abdomen, and pelvis, as well as gastric MRI for tumor staging, and who are planned for preoperative (neo)adjuvant therapy after multidisciplinary team (MDT) discussion; patients with advanced gastric cancer who are confirmed by postoperative pathology to require (neo)adjuvant therapy.
* The patient or their family members are able to comprehend the research protocol and are willing to participate in this study, providing written informed consent.