Outcome of Radiation Therapy in Operated Gastric Cancer

NCT ID: NCT04810663

Last Updated: 2021-03-23

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 40 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-04-01
• Study Completion Date: 2023-04-01

Brief Summary

• Study tolerability and toxicity of radiotherapy with or without chemotherapy for operated gastric cancer.
• Evaluate the efficacy of adjuvant radiotherapy with or without chemotherapy as regarding local control and overall survival.

Conditions

Gastric Adenocarcinoma

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Interventions

Radiotherapy

Adjuvant Radiotherapy in operated gastric cancer

Intervention Type: RADIATION

Eligibility Criteria

Inclusion Criteria

• Age of the patient; ≥18 and ≤75 years.
• Histologically proven gastric or gastroesophageal adenocarcinoma.
• Pt received adjuvant Radiotherapy with or without chemotherapy with any protocol.

Exclusion Criteria

• Patient >75 years&<18 years.
• Histologically types other than adenocarcinoma .
• Metastatic patients (M1).
• Pt didn't recive radiotherapy.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Mohamed Ahmed Ezzat Mohamed

principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Mohamed Ahmed Ezzat, Master degree

Role: CONTACT

maezzatma9@gmail.com

+201068490648

References

1- A. Schernberg,a E. Rivin del Campo,a B. Rousseau,b O. Matzinger,c M. Loi,d P. Maingon,e,f and F. Hugue. Adjuvant chemoradiation for gastric carcinoma: State of the art and perspectives. ClinTranslRadiatOncol. 2018 Mar 13: 13-22. 2- Karimi P., Islami F., Anandasabapathy S., Freedman N.D., Kamangar F. Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomarkers Prev. 2014;23(5):700-713. 3- Forman D., Burley V.J. Gastric cancer: global pattern of the disease and an overview of environmental risk factors. Best Pract Res ClinGastroenterol. 2006;20(4):633-649. 4- Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11. Lyon, France: International Agency for Research on Cancer; 2013. [Internet]. [cited 2014 Feb 22]. Available from: <http://globocan.iarc.fr/Pages/references.aspx>. 5- Ministry of Health and Population. Gharbiah Population Based Cancer Registry, Egypt. .Cancer in Egypt, triennial report of 2000-2002. 2007. MOH: Tanta, Egypt. 6-Alieldin N. NCI hospital-based registry 2002-2010 [Internet]. [cited 2014 Feb23].Availablefrom:<http://nci.cu.edu.eg/App_Files/registry/NCI_registry%202002-2010.pdf>. 7-Freedman L, Edwards B, Ries L, Young J, editors. Cancer incidence in four member countries (Cyprus, Egypt, Israel, and Jordan) of the Middle East Cancer Consortium (MECC) Compared with US SEER. National Cancer Institute, 2006. NIH Pub. No. 06-5873. Bethesda, MD [Internet]. [cited 2014 Feb 22]. 8- Zhou XM, Wong BC, Fan XM, Zhang HB, Lin MC, Kung HF, et al. Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through upregulation of bax and bak. Carcinogenesis. 2001;22:1393-97 9-Sasazuki S, Inoue M, Iwasaki M, Otani T, Yamamoto S, Ikeda S, et al. Effect of helicobacter pylori infection combined with cagA and pepsinogen status on gastric cancer development among Japanese men and women: A nested case-control study. Cancer Epidemiol. Biomarkers Prev. 2006;15:1341-47. 10- Tomonaga M, Oka M, Narasaki F, Fukuda M, Nakano R, Takatani H, et al. The multidrug resistance-associated protein gene confers drug resistance in human gastric and colon cancers. Jpn J Cancer Res. 1996;87:1263-70. 11-Buckland G, Travier N, Huerta JM, et al. Healthy lifestyle index and risk of gastric adenocarcinomaintheEPIC cohort study.IntJ Cancer. 2015;137(3):598-606. 12-Massarrat S, Stolte M. Development of gastric cancer and its prevention. Arch Iran Med. 2014;17(7):514-520. 13-Zhang ZX, ,Gu XZ, , Yin WB, , Huang GJ, , Zhang DW, , Zhang RG. Randomized clinical trial on the combination of preoperative irradiation and surgery in the treatment of adenocarcinoma of gastric cardia (AGC)-report on 370 patients. Int J RadiatOncolBiolPhys 1998; 42: 929-34. 14- Macdonald JS, , Smalley SR, , Benedetti J, , Hundahl SA, , Estes NC, , Stemmermann GN, et al. . Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001; 345: 725-30. 15- M Fan W Hu Z Zhang. Chemoradiation for gastric cancer: controversies, updates and novel techniques. Br J Radiol July 2015; ( 88(1051).

Reference Type: RESULT

Other Identifiers

Radiotherapy in gastric cancer

Identifier Type: -

Identifier Source: org_study_id